Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4702
rs4702
FES ; FURIN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.720 GeneticVariation BEFREE By integrating CRISPR-mediated gene editing, activation and repression technologies to study one putative SZ eQTL (FURIN rs4702) and four top-ranked SZ eQTL genes (FURIN, SNAP91, TSNARE1 and CLCN3), our platform resolves pre- and postsynaptic neuronal deficits, recapitulates genotype-dependent gene expression differences and identifies convergence downstream of SZ eQTL gene perturbations. 31548722

2019
dbSNP: rs4702
rs4702
FES ; FURIN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.720 GeneticVariation BEFREE Our data reveal that schizophrenia-associated rs4702 G allele-specific downregulation of FURIN by miR-338-3p reduces mature BDNF production. 29499969

2018