| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.700 | Biomarker | disease | CTD_human | Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells. | 27222248 | 2016 | ||||
|
0.700 | Biomarker | disease | CTD_human | The BRAF V600E mutation is specifically associated with sporadic MSI+ CRCs with methylated MLH1, but is not associated with Lynch syndrome-related CRCs. | 25701956 | 2015 | ||||
|
0.700 | GeneticVariation | disease | UNIPROT | Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival. | 24455489 | 2014 | ||||
|
0.700 | Biomarker | disease | CTD_human | Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. | 25280562 | 2014 | ||||
|
0.700 | GeneticVariation | disease | UNIPROT | Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. | 23263490 | 2013 | ||||
|
0.700 | GeneticVariation | disease | UNIPROT | Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. | 21917714 | 2011 | ||||
|
0.700 | Biomarker | disease | CTD_human | We analyzed sporadic CRCs in Omani (of African origin, N = 61), Iranian (of Caucasian origin, N = 53) and African American (N = 95) patients for microsatellite instability, expression status of mismatched repair genes (hMLH1, hMSH2) and presence of the BRAF (V600E) mutation. | 18718023 | 2008 | ||||
|
0.700 | GeneticVariation | disease | UNIPROT | Here we show that BRAF mutations in colorectal cancers occur only in tumours that do not carry mutations in a RAS gene known as KRAS, and that BRAF mutation is linked to the proficiency of these tumours in repairing mismatched bases in DNA. | 12198537 | 2002 |