Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.700 Biomarker group CTD_human TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension. 27292124 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.700 Therapeutic group CTD_human TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension. 27292124 2016
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.700 Biomarker group CTD_human A custom rat and baboon hypertension gene array to compare experimental models. 22228705 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.700 Biomarker group CTD_human Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas. 20720404 2010
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.700 Biomarker group CTD_human The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. 20659135 2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		0.700 Biomarker group CTD_human Many recent studies have shown the involvement of matrix metalloproteinases (MMPs) in hypertension, particularly MMP-2. 18836702 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Biomarker group CTD_human These data highlight the potential utility of eNOS gene therapy in the treatment of hypertension and insulin resistance. 19008412 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Therapeutic group CTD_human These data highlight the potential utility of eNOS gene therapy in the treatment of hypertension and insulin resistance. 19008412 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.700 Biomarker group CTD_human Our findings suggest that PPAR-gamma may be a key regulator of blood-brain barrier permeability and a potential therapeutic target during hypertension. 19666838 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Biomarker group CTD_human Genetic and pharmacogenetic associations between NOS3 polymorphisms, blood pressure, and cardiovascular events in hypertension. 19407804 2009
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1 		0.700 Biomarker group CTD_human Genome-wide association study of blood pressure and hypertension. 19430479 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Therapeutic group CTD_human Genetic and pharmacogenetic associations between NOS3 polymorphisms, blood pressure, and cardiovascular events in hypertension. 19407804 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.700 Therapeutic group CTD_human Our findings suggest that PPAR-gamma may be a key regulator of blood-brain barrier permeability and a potential therapeutic target during hypertension. 19666838 2009
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1 		0.700 Biomarker group CTD_human A critical role for vascular smooth muscle in acute glucocorticoid-induced hypertension. 18434569 2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1 		0.700 Biomarker group CTD_human Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine beta-synthase and apolipoprotein A-I. 18224302 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Therapeutic group CTD_human Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. 16331104 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Biomarker group CTD_human Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. 16331104 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.700 Therapeutic group CTD_human Three individuals with loss-of-function mutations of peroxisome proliferator-activated receptor gamma developed early hypertension. 15199296 2004
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.700 Biomarker group CTD_human Three individuals with loss-of-function mutations of peroxisome proliferator-activated receptor gamma developed early hypertension. 15199296 2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Biomarker group CTD_human Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. 12947532 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Therapeutic group CTD_human Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. 12947532 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Biomarker group CTD_human Insulin resistance in eNOS(-/-) mice was related specifically to impaired NO synthesis, because in equally hypertensive 1-kidney/1-clip mice (a model of renovascular hypertension), insulin-stimulated glucose uptake was normal. 11457755 2001
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.700 Therapeutic group CTD_human Insulin resistance in eNOS(-/-) mice was related specifically to impaired NO synthesis, because in equally hypertensive 1-kidney/1-clip mice (a model of renovascular hypertension), insulin-stimulated glucose uptake was normal. 11457755 2001
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2 		0.700 Biomarker group CTD_human Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure. 11082157 2000
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2 		0.700 Biomarker group CTD_human Recently, we have studied an unusual patient with mild low-renin hypertension and a homozygous mutation in the HSD11B2 gene. 9707624 1998