×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
BEFREE
Hypoprothrombinemia (OR 1.676, 95% CI 1.275-2.203) and prothrombin time (PT) prolongation (OR 2.050, 95% CI 1.398-3.005) were significantly associated with NMTT-cephalosporins, whereas bleeding was not (OR 1.359, 95% CI 0.920-2.009).
31623191
2019
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GermlineCausalMutation
disease
ORPHANET
A novel congenital dysprothrombinemia leading to defective prothrombin maturation.
25242243
2014
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
BEFREE
Prophylactic administration of prothrombin complex concentrates for congenital prothrombin deficiency with a novel frameshift mutation, prothrombin saitama.
23152198
2013
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GermlineCausalMutation
disease
ORPHANET
Congenital prothrombin deficiency: an update.
23852823
2013
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
CausalMutation
disease
CLINVAR
Thrombophilia: 2009 update.
19289024
2009
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
LHGDN
True congenital prothrombin deficiency due to a 'new' mutation in the pre-propeptide (ARG-39 GLN).
18852482
2008
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
Biomarker
disease
BEFREE
Prothrombin (factor II) deficiency is a rare autosomal recessive coagulation disorder that occurs in approximately 1 in 1-2 million people.
19141155
2008
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
LHGDN
Severe prothrombin deficiency caused by prothrombin-Edmonton (R-4Q) combined with a previously undetected deletion.
17002658
2006
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
LHGDN
Molecular genetics of hereditary prothrombin deficiency in Indian patients: identification of a novel Ala362 --> Thr (Prothrombin Vellore 1) mutation.
15892853
2005
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Prothrombin Shanghai: hypoprothrombinaemia caused by substitution of Gla29 by Gly.
14962227
2004
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
Biomarker
disease
BEFREE
The primary effect of this defect appears to be destabilization of the circulating prothrombin , creating a moderate hypoprothrombinemia .
14629473
2003
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
CausalMutation
disease
CLINVAR
Geographic distribution of the 20210 G to A prothrombin variant.
9569177
1998
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
AlteredExpression
disease
BEFREE
Cases with a parallel decrease in prothrombin activity and antigen should not be considered as examples of hypoprothrombinemia .
9863703
1998
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
Biomarker
disease
BEFREE
Automated fluorescence-based DNA sequence analysis of amplified genomic DNA was used to define prothrombin gene regions from a patient with severe functional hypoprothrombinemia and little detectable prothrombin antigen.
9351523
1997
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
BEFREE
The abnormal prothrombin gene of an Italian patient with a severe bleeding tendency and hypoprothrombinemia was selected for study and compared with the prothrombin genes of healthy controls.
9134629
1997
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala.
7792730
1995
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
BEFREE
A patient with a severe bleeding tendency and hypoprothrombinemia (Factor II activity 2%, Factor II antigen 5%) was screened for the presence of alterations in his prothrombin gene.
7740448
1994
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Prothrombin Padua I: incomplete activation due to an amino acid substitution at a factor Xa cleavage site.
7865694
1994
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).
1421398
1992
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Detection of a single base substitution of the gene for prothrombin Tokushima. The application of PCR-SSCP for the genetic and molecular analysis of dysprothrombinemia.
1349838
1992
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
Biomarker
disease
BEFREE
Molecular and genetic analysis of a compound heterozygote for dysprothrombinemia of prothrombin Tokushima and hypoprothrombinemia .
1334372
1992
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity.
1354985
1992
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity.
2719946
1989
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
Identification of the primary structural defect in the dysthrombin thrombin Quick I: substitution of cysteine for arginine-382.
3242619
1988
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.800
GeneticVariation
disease
UNIPROT
The prothrombin sample used was from a heterozygote but contained exclusively a defective prothrombin molecule, since the patient was heterozygous for both dysprothrombinemia and hypoprothrombinemia .
3567158
1987