Gene: NRAS ×
Source: INFERRED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 GeneticVariation disease CLINVAR Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma. 24918823 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo. 23431193 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. 23538902 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine. 22962325 2012
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR First-in-human, phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of RO5126766, a first-in-class dual MEK/RAF inhibitor in patients with solid tumors. 22761467 2012
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 GeneticVariation disease CLINVAR SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. 23076151 2012
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. 23076151 2012
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR NRAS-mutant melanoma: response to chemotherapy. 21576590 2011
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. 20406486 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells. 20149136 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. 21107323 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR These preliminary results suggest that BRAF and NRAS mutation status should be determined in prospective phase II studies of HSP90 inhibitors in melanoma. 18375819 2008
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 CausalMutation disease CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.700 Biomarker disease HPO