Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4160
Gene Symbol: MC4R
MC4R 		0.400 Biomarker disease CTD_human Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 29273807 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R 		0.400 Biomarker disease CTD_human Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in humans<sup>1-3</sup>. 29311635 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Therapeutic disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.400 Biomarker disease CTD_human A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. 9537324 1998
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.330 Biomarker disease CTD_human Genome wide association study identifies KCNMA1 contributing to human obesity. 21708048 2011
Entrez Id: 109
Gene Symbol: ADCY3
ADCY3 		0.310 Biomarker disease CTD_human Here we identify and functionally characterize homozygous mutations in the ADCY3 gene encoding adenylate cyclase 3 in children with severe obesity from consanguineous Pakistani families, as well as compound heterozygous mutations in a severely obese child of European-American descent. 29311637 2018
Entrez Id: 283455
Gene Symbol: KSR2
KSR2 		0.300 Biomarker disease CTD_human Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 29273807 2018
Entrez Id: 3778
Gene Symbol: KCNMA1
KCNMA1 		0.300 Biomarker disease CTD_human Genome wide association study identifies KCNMA1 contributing to human obesity. 21708048 2011