Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker disease BEFREE Most PCs were hormone-positive (n=12): ACTH (n=5), PRL (n=4), LH/FSH (n=2), GH (n=1). 31349217 2019
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker disease BEFREE Prolactin-Producing Pituitary Carcinoma, Hypopituitarism, and Graves' Disease-Report of a Challenging Case and Literature Review. 29928263 2018
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker disease CTD_human [Morphological changes in prolactinoma induced by bromocriptine treatment]. 2274009 1991
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Therapeutic disease CTD_human [Morphological changes in prolactinoma induced by bromocriptine treatment]. 2274009 1991
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Therapeutic disease CTD_human Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study. 3498743 1987
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker disease CTD_human Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study. 3498743 1987
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Therapeutic disease CTD_human Synergism of diethylstilbestrol and other carcinogens in concurrent development of hepatic, mammary, and pituitary tumors in castrated male rats. 6156259 1980
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.320 Biomarker disease CTD_human Synergism of diethylstilbestrol and other carcinogens in concurrent development of hepatic, mammary, and pituitary tumors in castrated male rats. 6156259 1980
Entrez Id: 2688
Gene Symbol: GH1
GH1 		0.300 Biomarker disease CTD_human Improvement of congestive heart failure after octreotide and transsphenoidal surgery in a patient with acromegaly. 19420816 2009
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CTD_human A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. 16391232 2006
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1 		0.300 Biomarker disease CTD_human Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas. 16977796 2006
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Biomarker disease CTD_human Successful pregnancy after bromocriptine therapy in an anovulatory woman complicated with ovarian hyperstimulation caused by follicle-stimulating hormone-producing plurihormonal pituitary microadenoma. 12727942 2003
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		0.300 Biomarker disease CTD_human Hepatobiliary and gastrointestinal manifestations of acromegaly. 1611713 1992
Entrez Id: 5395
Gene Symbol: PMS2
PMS2 		0.100 GeneticVariation disease CLINVAR
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.030 Biomarker disease BEFREE Most PCs were hormone-positive (n=12): ACTH (n=5), PRL (n=4), LH/FSH (n=2), GH (n=1). 31349217 2019
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.030 GeneticVariation disease BEFREE Here we present an uncommon case of ACTH-secreting PCs and explore the gene mutation following pituitary adenoma transformation. 30460199 2018
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.030 Biomarker disease BEFREE We present a 63-year-old man with an adrenocorticotropic hormone (ACTH)-secreting PC, causing visual loss.It was resected transsphenoidally. 28291643 2017
Entrez Id: 8864
Gene Symbol: PER2
PER2 		0.010 GeneticVariation disease BEFREE Age-adjusted Kaplan-Meier analyses were performed, comparing all-cause mortality (ACM) rates before the year 2006, the time of TMZ introduction ("period 1"), and afterwards ("period 2"), in patients harboring PC and APA. 31267325 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.010 GeneticVariation disease BEFREE To the best of our knowledge, this is the first documented rare PCs patient with novel gene mutations that included ATRX and PTEN in addition to TP53. 30460199 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX 		0.010 GeneticVariation disease BEFREE To the best of our knowledge, this is the first documented rare PCs patient with novel gene mutations that included ATRX and PTEN in addition to TP53. 30460199 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1 		0.010 Biomarker disease BEFREE These results indicate that the LGALS3, hASH1, ID2, and TLE-4 genes may have important roles in the development of pituitary carcinomas. 16943582 2006
Entrez Id: 7091
Gene Symbol: TLE4
TLE4 		0.010 Biomarker disease BEFREE These results indicate that the LGALS3, hASH1, ID2, and TLE-4 genes may have important roles in the development of pituitary carcinomas. 16943582 2006