Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease PSYGENET We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P < 0.05) in Caucasian subjects, but not African-American individuals. 24078558 2013
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease PSYGENET Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. 23635803 2013
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease PSYGENET Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. 22832851 2012
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. 18418874 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. 18418874 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. 16541082 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. 16541082 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 16971900 2006
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 16971900 2006
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. 15042275 2004
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. 15010698 2004
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. 15042275 2004
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. 15010698 2004
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Biomarker disease CTD_human Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. 10900248 2000
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.800 Therapeutic disease CTD_human Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. 10900248 2000