rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In all components (bilateral serous borderline tumors, low-grade serous carcinoma and mesonephric-like adenocarcinoma), an identical KRAS mutation was detected (NM_004985.4): c.35G>A, p.(G12D) proving a clonal association between the serous and mesonephric-like components and excluding a collision neoplasm.
|
30575604 |
2020 |
rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
After microdissecting and testing the adenocarcinoma and neuroendocrine components separately, it was found that the adenocarcinoma was positive for KRAS G12C mutation and the neuroendocrine component was positive for KRAS G12D mutation.
|
27597976 |
2016 |
rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Loss of the gene that encodes p16 (Cdkn2a) was required for progression of IPMNs to pancreatic ductal adenocarcinomas in Acvr1b(flox/flox);LSL-Kras(G12D);Pdx1-Cre mice.
|
26408346 |
2016 |
rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Malignant growths in the gp130(F/F):Kras(G12D) model displayed features of atypical adenomatous hyperplasia, adenocarcinoma in situ, and invasive adenocarcinoma throughout the lung, as compared with parental Kras(G12D) mice, where STAT3 was not hyperactivated.
|
26744530 |
2016 |
rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Transcriptional profiling of Kras(G12V)-driven mouse hyperplasias revealed intertumor diversity with a subset that exhibited an aggressive transcriptional profile analogous to that of advanced human adenocarcinomas.
|
26855149 |
2016 |
rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16 (HPV16) E6/E7 under the control of a tetracyclin-inducible promoter efficiently immortalized and transformed primary HPDECs, which gave rise to adenocarcinomas subcutaneously in an immune-deficient mouse xenograft model, depending on expression of the four genes.
|
24858378 |
2014 |
rs121913529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Through two novel transgenic mouse models, we show that Twist1 cooperates with Kras(G12D) to markedly accelerate lung tumorigenesis by abrogating cellular senescence programs and promoting the progression from benign adenomas to adenocarcinomas.
|
22654667 |
2012 |
rs121913530
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Analysis of the KRAS gene showed only a G12C variation in one large cell carcinoma (LCC) patient, whereas variants were not found in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) cases.
|
30048458 |
2018 |
rs121913530
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, KRAS gene exon 2 G12C presented mutation in the OSP-associated adenocarcinoma.
|
29879069 |
2018 |
rs121913530
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Seven of 17 cases (41%) were reclassified in the adenocarcinoma with solid pattern group, which showed one KRAS G12C and one EGFR E709K + G719C double mutation in addition to mutations in TP53.
|
26430808 |
2016 |
rs121913530
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After microdissecting and testing the adenocarcinoma and neuroendocrine components separately, it was found that the adenocarcinoma was positive for KRAS G12C mutation and the neuroendocrine component was positive for KRAS G12D mutation.
|
27597976 |
2016 |
rs112445441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Analysis indicated one SCC patient (2.3%) exhibited a KRAS p.G13D mutation, and one adenocarcinoma patient (2.3%) exhibited a BRAF p.V600E mutation.
|
27573925 |
2016 |
rs112445441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We report here two cases of ALK-rearranged adenocarcinomas harboring concomitant exon 2 K-RAS mutations (G13D and Q61H).
|
26898615 |
2016 |
rs17851045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report here two cases of ALK-rearranged adenocarcinomas harboring concomitant exon 2 K-RAS mutations (G13D and Q61H).
|
26898615 |
2016 |