|
rs63750734
|
|
|
0.730 |
GeneticVariation |
UNIPROT |
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
|
9328472 |
1997 |
|
rs63750064
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
|
9328472 |
1997 |
|
rs63749964
|
|
|
0.710 |
GeneticVariation |
UNIPROT |
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
|
9328472 |
1997 |
|
rs63750399
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
|
9328472 |
1997 |
|
rs63750643
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
|
9328472 |
1997 |
|
rs63750264
|
|
|
0.900 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750671
|
|
|
0.760 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750066
|
|
|
0.730 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750734
|
|
|
0.730 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750064
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63749964
|
|
|
0.710 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750399
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750643
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
|
1302033 |
1992 |
|
rs63750847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A rare amyloid precursor protein gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer's disease and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations.
|
24529499 |
2014 |
|
rs63750734
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A rare variant in PLD3 (phospholipase D3; Val232Met) segregated with disease status in two independent families and doubled risk for Alzheimer's disease in seven independent case-control series with a total of more than 11,000 cases and controls of European descent.
|
24336208 |
2014 |
|
rs1223904774
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A rare variant in PLD3 (phospholipase D3; Val232Met) segregated with disease status in two independent families and doubled risk for Alzheimer's disease in seven independent case-control series with a total of more than 11,000 cases and controls of European descent.
|
24336208 |
2014 |
|
rs200620364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare variant in PLD3 (phospholipase D3; Val232Met) segregated with disease status in two independent families and doubled risk for Alzheimer's disease in seven independent case-control series with a total of more than 11,000 cases and controls of European descent.
|
24336208 |
2014 |
|
rs772069024
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare variant in PLD3 (phospholipase D3; Val232Met) segregated with disease status in two independent families and doubled risk for Alzheimer's disease in seven independent case-control series with a total of more than 11,000 cases and controls of European descent.
|
24336208 |
2014 |
|
rs63750264
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A second member of the original family with the valine to isoleucine substitution at codon 717 of the amyloid precursor protein died after the clinical diagnosis of Alzheimer's disease had been made in life.
|
8084541 |
1994 |
|
rs1223904774
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A triple transgenic mouse model of AD (3xTg-AD) which harbors mutations in three human transgenes, APP(Swe), PS1(M146V) and Tau(P301L), was used in these experiments.
|
21237293 |
2011 |
|
rs1386984902
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A triple transgenic mouse model of AD (3xTg-AD) which harbors mutations in three human transgenes, APP(Swe), PS1(M146V) and Tau(P301L), was used in these experiments.
|
21237293 |
2011 |
|
rs63750847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.
|
23652020 |
2013 |
|
rs63750066
|
|
|
0.730 |
GeneticVariation |
BEFREE |
According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy.
|
28304299 |
2017 |
|
rs364048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustments for age, sex, and APOE ε4 status, only one target SNP, rs463946 was associated with the risk of sAD in the dominant (OR 1.52, 95 % CI 1.01-2.29, P = 0.045) and overdominant models (OR 1.59, 95 % CI 1.04-2.43, P = 0.031); the results also showed a borderline association of rs364048 (OR 1.53, 95 % CI 1.00-2.34, P = 0.048) and rs466433 (OR 1.53, 95 % CI 1.00-2.34, P = 0.048) with the risk of sAD in the overdominant model.
|
25631235 |
2015 |
|
rs466433
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustments for age, sex, and APOE ε4 status, only one target SNP, rs463946 was associated with the risk of sAD in the dominant (OR 1.52, 95 % CI 1.01-2.29, P = 0.045) and overdominant models (OR 1.59, 95 % CI 1.04-2.43, P = 0.031); the results also showed a borderline association of rs364048 (OR 1.53, 95 % CI 1.00-2.34, P = 0.048) and rs466433 (OR 1.53, 95 % CI 1.00-2.34, P = 0.048) with the risk of sAD in the overdominant model.
|
25631235 |
2015 |