|
rs1035071612
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our data suggested that the polymorphism of LRP C766T was strongly associated with AD and T allele might be a protective factor for AD in Chinese Han population.
|
18706476 |
2008 |
|
rs1035071612
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the present study, we have investigated the extent of amyloid beta protein (Abeta) deposition as cerebral amyloid angiopathy (CAA) or senile plaques (SP) in relationship to OLR1 +1071 and +1073 polymorphisms and LRP1 C766T polymorphism in patients with AD There was an increased Abeta40 load as CAA, but not as SP, in frontal cortex of AD patients carrying OLR1+1073 CC genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele.
|
16328515 |
2006 |
|
rs1035071612
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In addition, the C766T polymorphism was shown not to influence the age onset of AD.
|
15925094 |
2005 |
|
rs1035071612
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The C-allele of the silent C766T polymorphism in exon 3 of the LRP gene might be associated with AD, however, results are conflicting and thus discussed controversially.
|
12898587 |
2003 |
|
rs1035071612
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recently, several studies have reported a correlation between a polymorphism (C766T) in exon 3 of LRP and AD.
|
10027548 |
1999 |
|
rs1035071612
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The LRP C766T polymorphism is protective against Alzheimer's disease, perhaps through alteration of LRP expression.
|
9832203 |
1998 |
|
rs5930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to investigate the association between polymorphisms in several cholesterol-related genes [APOA5 (rs662799), APOC1 (rs11568822), APOD (rs1568565), CH25H (rs13500), LDLR (rs5930), SORL1 (rs2282649)] and AD in a cohort of Turkish patients.
|
30684189 |
2019 |
|
rs875989939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our interest in these mutations was initiated by studying the potential effects of the A539T substitution in the butyrylcholinesterase BChE-K variant on amyloid fibrils formation in Alzheimer's disease.
|
20060816 |
2010 |
|
rs1172805138
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17Thr, bleomycin hydrolase I443V, lectin-like oxidized low-density lipoprotein receptor (OLR1) 3'-UTR (+1071) and (+1073), and very-low-density lipoprotein receptor (VLDLR) 5'-UTR (CGG-repeat) polymorphisms.
|
17854420 |
2008 |
|
rs148181903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17Thr, bleomycin hydrolase I443V, lectin-like oxidized low-density lipoprotein receptor (OLR1) 3'-UTR (+1071) and (+1073), and very-low-density lipoprotein receptor (VLDLR) 5'-UTR (CGG-repeat) polymorphisms.
|
17854420 |
2008 |
|
rs688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lastly, we evaluated whether rs688 associates with AD by genotyping DNA from 1457 men and 2055 women drawn from three case-control series.
|
18065781 |
2008 |
|
rs688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs688T/T genotype was associated with increased AD odds in males [recessive model, odds ratio (OR) of 1.49, 95% confidence interval (CI) of 1.13-1.97, uncorrected P = 0.005], but not in females.
|
18065781 |
2008 |
|
rs879255085
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17Thr, bleomycin hydrolase I443V, lectin-like oxidized low-density lipoprotein receptor (OLR1) 3'-UTR (+1071) and (+1073), and very-low-density lipoprotein receptor (VLDLR) 5'-UTR (CGG-repeat) polymorphisms.
|
17854420 |
2008 |