Gene: IL33 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs928413
rs928413
IL33
G 0.800 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433

2019
dbSNP: rs928413
rs928413
IL33
G 0.800 GeneticVariation GWASCAT Identification of a new locus at 16q12 associated with time to asthma onset. 27130862

2016
dbSNP: rs928413
rs928413
IL33
0.800 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010
dbSNP: rs146597587
rs146597587
IL33 ; LOC107987046
G 0.720 GeneticVariation GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474

2019
dbSNP: rs146597587
rs146597587
IL33 ; LOC107987046
0.720 GeneticVariation BEFREE Together these data demonstrate that rs146597587-C is a loss of function mutation and support the hypothesis that IL-33 haploinsufficiency protects against asthma. 28273074

2017
dbSNP: rs146597587
rs146597587
IL33 ; LOC107987046
0.720 GeneticVariation BEFREE This includes a rare splice acceptor variant (rs146597587, MAF = 0.5%) in interleukin 33 (IL33) associated with reduced eosinophil count (P = 2.4x10-23), and lower risk of asthma (P = 2.6x10-7, odds ratio [95% confidence interval] = 0.56 [0.45-0.70]) and allergic rhinitis (P = 4.2x10-4, odds ratio = 0.55 [0.39-0.76]). 28787443

2017
dbSNP: rs7848215
rs7848215
IL33
T 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433

2019
dbSNP: rs7848215
rs7848215
IL33
T 0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738

2019
dbSNP: rs12339348
rs12339348
IL33 ; LOC107987046
0.700 GeneticVariation GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011

2018
dbSNP: rs17498196
rs17498196
IL33 ; LOC107987046
0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010
dbSNP: rs2066362
rs2066362
IL33
0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010
dbSNP: rs7044343
rs7044343
IL33 ; LOC107987046
0.010 GeneticVariation BEFREE No association was found between rs7044343 variant and asthma. 28985997

2018
dbSNP: rs12551256
rs12551256
IL33 ; LOC107987046
0.010 GeneticVariation BEFREE The G allele of IL33 SNP rs12551256 was negatively associated with asthma (OR 0.71, 95% CI: 0.53-0.94, P = 0.017). 28266165

2017