|
rs4129267
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with respect to asthma severity.
|
22554704 |
2012 |
|
rs4129267
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
|
21907864 |
2011 |
|
rs2228145
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aims of this study were to evaluate whether there is an association between Asp358Ala</span> and COPD or asthma risk, and to explore the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effects in the lung.
|
28334838 |
2017 |
|
rs2228145
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results provide evidence that rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma.
|
26997259 |
2016 |
|
rs2228145
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, the variant's effect on IL-6 signaling is not known.
|
23593036 |
2013 |
|
rs2228145
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The IL6R coding SNP rs2228145 (Asp(358)Ala) is a potential modifier of lung function in subjects with asthma and might identify subjects at risk for more severe asthma.
|
22554704 |
2012 |
|
rs12083537
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results provide evidence that rs2228145 C and rs12083537 G are associated with poor lung function in patients with asthma.
|
26997259 |
2016 |
|
rs12083537
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the other hand, results from 16,705 asthmatics and 30,809 controls showed that the rs12083537:A allele increased asthma risk by 1.04-fold (P=0.0419).
|
23945879 |
2013 |