| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
C | 0.710 | GeneticVariation | GWASCAT | Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. | 30061737 | 2018 |
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0.710 | GeneticVariation | BEFREE | Both rs35594137 and rs10465885 were tested for association with early-onset lone AF (≤60 years of age) in 384 cases and 3010 population control subjects. rs10465885 was associated with the AF phenotype (odds ratio, 1.18; P=0.046). | 21076161 | 2011 |
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|
0.030 | GeneticVariation | BEFREE | Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19-0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20-4.42; p = 0.012). | 31270966 | 2019 |
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|
0.030 | GeneticVariation | BEFREE | Cx 40 (rs35594137) differences between AF </span>and control groups of Han origin were not significant (P > 0.05), but were statistically significant in the Uygur population (P < 0.05). | 26634538 | 2015 |
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|
0.030 | GeneticVariation | BEFREE | Both rs35594137 and rs10465885 were tested for association with early-onset lone AF (≤60 years of age) in 384 cases and 3010 population control subjects. rs10465885 was associated with the AF phenotype (odds ratio, 1.18; P=0.046). | 21076161 | 2011 |
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|
0.010 | GeneticVariation | BEFREE | The A96S, G38D, and P88S Cx40 mutations slow conduction and increased the propensity for inducible AF. | 28457700 | 2018 |
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0.010 | GeneticVariation | BEFREE | These findings provide evidence that the Q49X mutant is capable of impairing gap-junction distribution and function of key atrial connexins, which might play a role in the predisposition to and onset of AF. | 24626989 | 2014 |