Gene: STAT3 ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs744166
rs744166
STAT3
0.030 GeneticVariation BEFREE This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians. 25286337

2014
dbSNP: rs744166
rs744166
STAT3
0.030 GeneticVariation BEFREE We could confirm the susceptibility of STAT3 rs744166 TT homozygotes for UC (OR: 1.483, 95% CI: 1.103-1.992, P = 0.009). 22269120

2012
dbSNP: rs744166
rs744166
STAT3
0.030 GeneticVariation BEFREE Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC. 22065112

2012
dbSNP: rs2293152
rs2293152
STAT3
0.020 GeneticVariation BEFREE While rs2293152</span> (GC) was protective, rs2293152 (CC) increased the susceptibility to ulcerative colitis (p=0.009, p=0.001). 27852544

2016
dbSNP: rs2293152
rs2293152
STAT3
0.020 GeneticVariation BEFREE Our study implies that the STAT3 rs2293152</span> polymorphism may be associated with the occurrence of UC and might be used as a predictive factor for UC in the Chinese Han population. 24781989

2014
dbSNP: rs113994136
rs113994136
STAT3
0.010 GeneticVariation BEFREE Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans. 26887945

2016
dbSNP: rs3816769
rs3816769
STAT3
0.010 GeneticVariation BEFREE Additionally, rs10758669 and rs2293152 in Crohn's disease and rs8074524, rs3816769, and rs10758669 in ulcerative colitis were associated with the requirement of immunsuppression. 27852544

2016
dbSNP: rs8074524
rs8074524
STAT3
0.010 GeneticVariation BEFREE Finally, rs8074524 and rs10758669 in Crohn's disease and rs11209026 in ulcerative colitis were associated with disease-related operation. 27852544

2016
dbSNP: rs4796793
rs4796793
STAT3
0.010 GeneticVariation BEFREE However, we failed to find any obvious differences in the rs4796793 genotype or allele distributions between the UC patients and controls, and did not detect any significant association of the rs4796793 polymorphism with UC across different genetic models of inheritance. 24781989

2014