rs2476601
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) rs2476601 within the PTPN22 gene locus results in aberrant function of PTPN22 protein and protects from Crohn's disease (CD).
|
27467733 |
2016 |
rs2476601
|
|
|
0.860 |
GeneticVariation |
BEFREE |
After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.
|
24971461 |
2014 |
rs2476601
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our data not only demonstrate a critical role of PTPN22 in regulating macrophage polarization but also provide a molecular explanation for the protective effect of the C1858T SNP in Crohn's disease.
|
23913970 |
2013 |
rs2476601
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The R263Q polymorphism only associated with UC, whereas the R620W was significantly associated with only CD.
|
21287672 |
2011 |
rs2476601
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In a multiple logistic regression model, the strongest association with CD was found for the 1007fs variant (OR = 4.6, 95% CI 3.0-7.0), followed by p.G908R (OR = 2.9, 95% CI 1.5-5.7) and p.R702W (OR = 1.7, 95% CI 1.0-2.9), while no independent association was found for the remaining variants in the CARD15 gene (p.268S, p.955I and p.289S), for the p.R620W variant in the PTPN22 gene or for the g.-308G>A variant in the TNFA gene.
|
18489434 |
2008 |
rs2476601
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Here, we analysed the functionally relevant polymorphism R620W (rs 2476601) of the PTPN22 gene in 146 patients suffering from CD using restriction fragment length polymorphism (RFLP) analyses.
|
16164701 |
2005 |
rs33996649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R263Q polymorphism only associated with UC, whereas the R620W was significantly associated with only CD.
|
21287672 |
2011 |