|
rs25531
|
|
|
0.100 |
GeneticVariation |
BEFREE |
1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
|
22520017 |
2012 |
|
rs6313
|
|
|
0.050 |
GeneticVariation |
BEFREE |
5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine.
|
18801406 |
2008 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
|
18347599 |
2008 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
|
18347599 |
2008 |
|
rs738499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Depression and disease severity are the main contributors to these findings, but rs738499 itself is an independent risk factor.
|
22257907 |
2012 |
|
rs25531
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures.
|
28024274 |
2017 |
|
rs553040076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Q31L mutants had lower PDE4B activity, consistent with their resistance to rolipram, suggesting decreased PDE4 activity as a contributory factor in depression.
|
17481393 |
2007 |
|
rs16139
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Leu7Pro was analyzed in a large well-characterized longitudinal population-based sample of adult Swedes with data on life situation and life history, including 461 with depression diagnosis, 157 with anxiety diagnosis and 1514 healthy individuals with no symptom of psychopathology.
|
19264362 |
2009 |
|
rs397514679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Q555X-hSynI induced larger facilitation and post-tetanic potentiation in excitatory synapses and stronger depression after long trains in inhibitory synapses.
|
23406870 |
2013 |
|
rs33939927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R1441G carriers scored higher in motor scores, had lower radioligand uptake, and had higher scores in depression, dysautonomia, and Rapid Eye Movements Sleep Behavior Disorder Screening Questionnaire scores, but had better cognition scores than noncarriers.
|
28370517 |
2017 |
|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Asp358Ala was not associated with total depression score.
|
29197507 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
rs53576
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443).
|
28499211 |
2017 |
|
rs5443
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443).
|
28499211 |
2017 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults.
|
23475824 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genetic variant (rs6265) of the brain-derived neurotrophic factor (BDNF) impacting on emotion processing is known to increase the risk for depression.
|
25998702 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
|
22610920 |
2012 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
|
22610920 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
|
rs41305272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |