|
rs139832701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant effect of OXTR genotype on DASS anxiety, stress and depression scores was found and ELS events, in combination with several different OXTR SNPs, were significantly associated with differences in DASS scores with one SNP (rs139832701) showing significant association or a trend towards association for all three measures.
|
25262417 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
rs53576
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP) of the oxytocin receptor gene (OXTR), rs53576, and a SNP of the CD38 gene, which regulates oxytocin secretion, rs3796863, have been associated with depression and suicidal ideation.
|
29860184 |
2018 |
|
rs3796863
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP) of the oxytocin receptor gene (OXTR), rs53576, and a SNP of the CD38 gene, which regulates oxytocin secretion, rs3796863, have been associated with depression and suicidal ideation.
|
29860184 |
2018 |
|
rs3782218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05).
|
24917196 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
|
18450378 |
2008 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
|
18450378 |
2008 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
rs977605156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
rs9470080
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjusting for covariates, the main and gene-environment interaction effects of rs9470080 were all significant when the combined PTSD-depression group was compared with the low symptoms, predominantly depression and predominantly PTSD groups. rs9470080 TT genotype carriers had a higher risk of developing high co-occurring PTSD and depression symptoms than the C allele carriers.
|
31510784 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
|
17911362 |
2007 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
|
17911362 |
2007 |
|
rs11636753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, rs11636753 in CHRNB4 showed suggestive association with regular drinking (p = .0029) and the comorbidity of depression and ND (p = .0034).
|
22241830 |
2012 |
|
rs10510057
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although none surpassed the level of the genome-wide significance, a marginal significant association of interaction between SRRS and rs10510057 with depression were found (p = 4.5 × 10-8).
|
27529621 |
2016 |
|
rs25531
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression.
|
22094432 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the current study found no association between COMT Val(158)Met polymorphism on a number of clinical neuropsychological tests that are typically found to be sensitive to depression, differential effects of the COMT Val(158)Met polymorphism on dopamine transmission in psychiatric and non-psychiatric populations may be further clarified by clinical research with neuroscience-based paradigms that segregate cognitive tasks into component processes with precise neural substrates, particularly with respect to the complex functions of the prefrontal cortex.
|
19296553 |
2009 |
|
rs63751273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among 31 previously reported cases bearing the P301L tau mutation for which the data regarding initial symptoms are available, one clinical case showed only apathy with depression in the early stage.
|
29105852 |
2018 |
|
rs78162420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among patients with PD, depression is associated with polymorphism at rs78162420 and rs1545843, both previously linked with depression.
|
28320136 |
2017 |
|
rs1545843
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among patients with PD, depression is associated with polymorphism at rs78162420 and rs1545843, both previously linked with depression.
|
28320136 |
2017 |
|
rs885479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the common SNPs, the nonsynonymous SNP, rs885479 (R163Q) was associated with the diagnosis of depression (P=0.04).
|
21052032 |
2011 |
|
rs1364647619
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the common SNPs, the nonsynonymous SNP, rs885479 (R163Q) was associated with the diagnosis of depression (P=0.04).
|
21052032 |
2011 |
|
rs2910709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.
|
24022000 |
2013 |
|
rs884344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.
|
24022000 |
2013 |