|
rs4986790
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population.
|
28620993 |
2017 |
|
rs4986790
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results of our study demonstrated that the G allele of the Asp299Gly polymorphism of the TLR4 gene is associated with increased risk of cardiovascular disease and diabetic retinopathy in type 2 diabetes patients.
|
27321310 |
2016 |
|
rs4986790
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present meta-analysis indicates that TLR4 gene Asp299Gly and Thr399Ile polymorphisms are not associated with increased T2DM risk.
|
25648392 |
2015 |
|
rs4986791
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present meta-analysis indicates that TLR4 gene Asp299Gly and Thr399Ile polymorphisms are not associated with increased T2DM risk.
|
25648392 |
2015 |
|
rs4986791
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabetic foot ulcer (DFU) risk in patients with type 2 diabetes mellitus (T2DM).
|
23936790 |
2013 |
|
rs4986790
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In contrast, the 299Gly allele and the 399Ile allele from the Asp299Gly and Thr399Ile TLR4 gene polymorphisms, respectively, were associated with protection of T2DM.
|
19395279 |
2010 |
|
rs4986791
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In contrast, the 299Gly allele and the 399Ile allele from the Asp299Gly and Thr399Ile TLR4 gene polymorphisms, respectively, were associated with protection of T2DM.
|
19395279 |
2010 |
|
rs4986790
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
|
14693986 |
2004 |
|
rs4986791
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
|
14693986 |
2004 |
|
rs4986791
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We studied the prevalence of two common polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) in 3 independent study populations: (1.) in a cross-sectional study including 769 patients either with type 1 or type 2 diabetes mellitus, of whom 56 (7.2%) had a history of cerebral ischemia (study 1), (2.) a case-control study (study 2) including 128 consecutive patients with cerebral ischemia, mean age 60 +/- 10.9 years and 139 control subjects, and (3.) a case-control study (study 3) including 171 young adults aged < 50 years with cerebral ischemia and 204 control individuals.
|
15258789 |
2004 |
|
rs1927911
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, P = 0.002 for rs10759932, odds ratio 1.136, P = 0.009 for rs1927911</span>, odds ratio 0.882, P = 0.024 for rs11536889).
|
25104099 |
2015 |
|
rs1927911
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study suggested that rs1927914 and rs1927911 were associated with type 2 diabetes mellitus and that rs1927914 was associated with susceptibility to DR in a Han Chinese population.
|
25947554 |
2015 |
|
rs1927914
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study suggested that rs1927914 and rs1927911 were associated with type 2 diabetes mellitus and that rs1927914 was associated with susceptibility to DR in a Han Chinese population.
|
25947554 |
2015 |
|
rs1927914
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results of the present case-control study that included 698 north Indian subjects suggested that TLR4 SNPs rs10759931 and rs1927914 modulate the risk of DR in T2DM cases.
|
24883015 |
2014 |
|
rs1927911
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabetic foot ulcer (DFU) risk in patients with type 2 diabetes mellitus (T2DM).
|
23936790 |
2013 |
|
rs1927914
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabetic foot ulcer (DFU) risk in patients with type 2 diabetes mellitus (T2DM).
|
23936790 |
2013 |
|
rs7873784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We hypothesize that additional functional PU.1 site may increase TLR4 expression in individuals carrying minor C variant of rs7873784 and modulate the development of certain pathologies, such as rheumatoid arthritis and type-2 diabetes mellitus.
|
31785408 |
2020 |
|
rs5030718
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Role of variants rs5030717 and rs5030718 of TLR4 in the risk prediction of nephropathy, hypertension and dyslipidaemia in type 2 diabetes mellitus.
|
30211669 |
2018 |
|
rs7873784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotypes GG (OR = 0.09, 95%CI = 0.01- 0.83, P = 0.03) and CG (OR = 0.08, 95%CI = 0.01-0.74, P = 0.03) of the 3'-untranslated region (UTR) SNP rs7873784 in TLR4, and genotype AG (OR = 0.67, 95%CI = 0.46-0.97, P = 0.04) and allele G (OR = 0.88, 95%CI = 0.79-0.97, P = 0.01) of the intron SNP rs1898830 in TLR2 were identified as protective against the development of T2DM in southern Chinese people.
|
26345801 |
2015 |
|
rs5030718
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The allele A of g.14367G>A variants may contribute to the susceptibility to T2DM.
|
24085443 |
2013 |
|
rs5030717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Role of variants rs5030717 and rs5030718 of TLR4 in the risk prediction of nephropathy, hypertension and dyslipidaemia in type 2 diabetes mellitus.
|
30211669 |
2018 |
|
rs10759932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, P = 0.002 for rs10759932, odds ratio 1.136, P = 0.009 for rs1927911, odds ratio 0.882, P = 0.024 for rs11536889).
|
25104099 |
2015 |
|
rs11536889
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, P = 0.002 for rs10759932, odds ratio 1.136, P = 0.009 for rs1927911, odds ratio 0.882, P = 0.024 for rs11536889).
|
25104099 |
2015 |
|
rs199930089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele-C and genotype-CC of g.13726T>C and allele-A and genotype-AA of g.15090G>A genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM.
|
25479716 |
2015 |
|
rs2149356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in TLR4 (rs1927911, rs11536889, rs1927907, rs1927906, rs1927914, rs7873784, and rs2149356) and TLR2 (rs1898830, rs3804099, rs4696480, and rs3804100) were genotyped in 552 T2DM and 552 unrelated age- and gender-matched controls by SNaPShot Multiplex assay.
|
26345801 |
2015 |