|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of the study were (i) to assess the distribution of the angiotensin II type 1 receptor (AGTR1) gene 1166A/C polymorphism and two polymorphisms of the angiotensinogen (AGT) gene (Met235Thr and Thr174Met) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent coronary angiography, compared with healthy volunteers; (ii) to determine if there was any correlation between these polymorphisms and risk of STEMI; and (iii) to assess the association of the examined polymorphisms with such classic cardiovascular risk factors as hypertension, diabetes mellitus, obesity (based on a body mass index ≥25 kg/m2), smoking, dyslipidemia, and family history of cardiovascular disease.
|
21657802 |
2011 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Molecular variants (M235T and T174M) in the angiotensinogen (AGT) gene and a mutation in the promoter region that involves the presence of an adenine (A) instead of a guanine (G) 6 bp upstream from the transcription initiation site (G-6A) have been reported to have a positive correlation with hypertension.
|
12051013 |
2002 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The occurrence of the frequent ABCC6 gene mutation c.3421C>T (R1141X) and the hypertension-associated genetic variants T174M and M235T in the angiotensinogen (AGT) gene were determined.
|
16133423 |
2005 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two mutations (T174M and M235T) in the angiotensinogen gene have been reported to be associated with hypertension.
|
7946168 |
1994 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Statistically significant associations with hypertension were identified for the T174M (odds ratio [OR]: 1.19; 95% CI: 1.07 to 1.33; P=0.002) and G-217A (OR: 1.37; 95% CI: 1.17 to 1.59; P=0.00006) polymorphisms.
|
18227406 |
2008 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the association among the M235T and T174M variants of the angiotensinogen (AGT) gene, plasma AGT, and hypertension status in a sample of Nigerians.
|
9170394 |
1997 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a polymorphism in the angiotensinogen gene substituting methionine for threonine (T174M) has been associated with hypertension in nondiabetic populations.
|
8593944 |
1996 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the T174M-T235T genotype was more common in the first quintile group, and showed significant association (P=0.05) with the group that had no family history of hypertension.
|
12113411 |
2002 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics.
|
18497458 |
2008 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evidence on the effect of salt intake on the interaction between angiotensinogen (AGT) T174M polymorphism and high blood pressure is sparse.
|
15055256 |
2004 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the polymorphic variants of AGT gene-M235T and T174M-show association with hypertension.
|
22148914 |
2012 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T and T174M variants, especially the T235 allele, contribute to an increased risk of hypertension in these Chinese patients.
|
20216084 |
2010 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no statistical association between the T174M polymorphism and hypertension risk in all subjects, in a Han Chinese subgroup or in non-Han Chinese minorities.
|
21881578 |
2012 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To further detect the influence of AGT gene single nucleotide polymorphisms (SNPs) in lead-induced hypertension, two SNPs (rs699 and rs4762) were genotyped in a case-control study including 219 lead-exposed subjects and 393 controls.
|
26818744 |
2016 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the whole population blood pressure levels and prevalence of high blood pressure did not vary according to T1</span>74M and M235T genotypes.
|
7622852 |
1995 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population.
|
23716723 |
2014 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants and hypertension in the Hani and Yi minority groups of China.
|
19365726 |
2009 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AGT T174M and ACE I/D polymorphisms were not associated with hypertension.
|
9533415 |
1998 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, this study provides no evidence that either allele of M235T or T174M contributes to hypertension in this Chinese population.
|
10024331 |
1999 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
So, the aim of current study was to develop efficient low-cost method for genotyping of cardiovascular disease and hypertension associated polymorphisms of AGT (rs4762, rs5051) and CYP11B1 (rs6410).
|
30478747 |
2019 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension.
|
23598646 |
2013 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.
|
15386947 |
2004 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was undertaken to investigate the relationship of the M235T polymorphism of the AGT gene with left ventricular mass (LVM) and carotid intima-media thickness (IMT) in 175 Chinese patients with hypertension.
|
10342781 |
1999 |