|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the polymorphic variants of AGT gene-M235T and T174M-show association with hypertension.
|
22148914 |
2012 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the basis of likelihood ratio test, only the set of haplotypes that constituted the A-6G and the M235T polymorphisms was associated with hypertension (chi2 = 20.91, P = 0.0008), which was mainly due to the increased frequency of the recombinant haplotypes (-6A identical with 235M and -6G identical with 235T), and a pathophysiological role in the predisposition to hypertension was hence indicated.
|
14970360 |
2004 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women.
|
10994750 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension.
|
16392768 |
2005 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease.
|
11463770 |
2001 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study.
|
18957799 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T and T174M variants, especially the T235 allele, contribute to an increased risk of hypertension in these Chinese patients.
|
20216084 |
2010 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ThrThr genotype of the angiotensinogen (AGT) Met235Thr polymorphism has been associated with elevated AGT levels, hypertension, increased heart disease risk, and improved blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitors.
|
14643574 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the T allele of the M235T polymorphism of the angiotensinogen gene was associated with a 3.19-fold increased risk for lesion progression independently of arterial hypertension.
|
12456049 |
2002 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants and hypertension in the Hani and Yi minority groups of China.
|
19365726 |
2009 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The angiotensinogen M235T polymorphism is positively associated with plasma angiotensinogen, hypertension, and coronary heart disease.
|
12040348 |
2002 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
|
12805070 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association study of G(-6)A, A(-20)C and M235T variants in 111 hypertensives with strong family history and 190 normotensives with no family history showed significant linkage disequilibrium between particular haplotypes, but we could find no association with hypertension.
|
10528248 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
18413162 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A DNA polymorphism which alters methionine to threonine at position 235 (M235T) within the angiotensinogen peptide has been associated previously with hypertension.
|
7635961 |
1995 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of AGT has been studied extensively in many populations including Japanese, and the results suggest a weak, but significant linkage with hypertension.
|
11128865 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The consistent relationships observed between the M235T variant and the protein product and between plasma level of the protein and hypertension status in different ethnic groups provide some evidence for a biochemical mechanism linking DNA variation in the renin-angiotensin system with the hypertension phenotype.
|
9170394 |
1997 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There are inconsistent reports that the angiotensinogen (ATG) variant Met235-->Thr (T235) allele and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) variants are associated with hypertension and related target organ damage.
|
10487325 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were no differences in the prevalence of hypertension and the ages at the ESRD in relation to the AGT M235T and ATR A1166C polymorphisms.
|
12950120 |
2003 |