|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relevance of the Glu298Asp polymorphism to hypertension in this population was tested in 2 ways.
|
10205226 |
1999 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Glu298Asp variant may be a genetic susceptibility factor for hypertension.
|
10883733 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multiple logistic regression revealed that the most predictive independent risk factor for coronary spasm was the T-786-->C mutation (P < 0.001), followed by cigarette smoking (P < 0.001), hypertension (P = 0.004), and the Glu298Asp variant (P = 0.028).
|
10979242 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recently identified a missense variant (Glu298Asp) that lies within exon 7 of the endothelial nitric oxide synthase (eNOS) gene, and that is associated with severe preeclampsia (proteinuric hypertension that develops as a consequence of pregnancy).
|
11354626 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension.
|
11710784 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-based cohort of hypertensive and control subjects.
|
11905585 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested no association between the Glu298Asp gene polymorphism and the incidence of hypertension in this selected population.
|
15475025 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the associations between the nitric oxide synthase gene (NOS3) Glu298Asp polymorphism and hypertension status or blood pressure (BP) levels have had inconsistent results.
|
15505116 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results do not support the hypothesis that the E298D polymorphism contributes to the genetic susceptibility to hypertension.
|
15942458 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out.
|
16940230 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Intron 4 B/B genotype was significantly associated with the hypertension group (P = 0.035), but disequilibrium of G894T and T-786C was absent between the two groups (P = 0.419 and P = 0.227), respectively.
|
17024134 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied eNOS polymorphisms in the promoter region (T-786C), in exon 7 (Glu298Asp), and in intron 4 (b/a) in 98 controls, 68 patients with HT, 66 patients with T2DM, and 86 patients with T2DM+HT.
|
17306574 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology.
|
17563560 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension.
|
17594145 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, meta-regression analysis indicated that the effect of the Glu298Asp genotype on the risk of hypertension might be dependent on total cholesterol status.
|
17762636 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AGT M235T and eNOS G894T polymorphisms are unlikely to play an important role in the pathogenesis of hypertension in Malays.
|
17977523 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure.
|
18164968 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype frequencies for the -786T/C, 4b/4a, and 894G/T polymorphisms differed significantly (P<0.001) between patients and controls and were associated with an increased risk of hypertension (OR=2.0, OR=3.8, OR=1.6, respectively).
|
18325347 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
|
18550157 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the present study support that homozygosity for +G894T (E298D) in NOS3 is a genetic risk factor for the development of LVH in patients with hypertension.
|
19132956 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
|
19169496 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |