|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant interaction between dietary fat intake and NOS3 Glu298Asp genotype with regards to hypertension status in either African Americans or whites (P for interaction=0.3 and 0.4, respectively).
|
19960019 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was an increased prevalence of hypertension and increased atria in Glu298Glu patients comparing with combined genotype Glu298Asp and Asp298Asp.
|
20079452 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents.
|
20661250 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
|
21912683 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias.
|
21912683 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension</span> in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs7830
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial NO synthase gene (odds ratio: 1.54 [95% CI: 1.37-1.73]; combined P=2.58 · 10(-13)).
|
22184326 |
2012 |
|
rs891512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients.
|
22425436 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636).
|
23122309 |
2012 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, rs3918226 in the eNOS promoter tags a hypertension susceptibility locus, TT homozygosity being associated with lesser transcription and higher risk of hypertension.
|
24019403 |
2013 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
For hypertension associations were seen for additional SNPs including NOS3 SNP rs3918226, previously associated with hypertension in genome-wide association study (GWAS) data.
|
24713495 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship between the G894T polymorphism and hypertension in Han Chinese may be attributed to the difference in geographic background of subjects.
|
24846690 |
2015 |
|
rs7830
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs3918188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs743506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk (OR = 0.77, 95% CI 0.55-1.08, P = 0.13) nor affected the hypertension risk (OR = 1.04, 95% CI 0.66-1.66, P = 0.86).
|
24995932 |
2014 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We recently identified rs3918226 as a hypertension susceptibility locus (-665 C>T), TT homozygosity being associated with higher hypertension risk.
|
25102225 |
2015 |