|
rs7671167
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our results were the first time to reveal that SNPs from FAM13A (rs7671167), SETD7 (rs17050782), and a haplotype of VEGFA ("GGCGC") are potential susceptibility loci associated with increased COPD risk in Chinese Li minority population.
|
26251585 |
2015 |
|
rs7671167
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The rs1903003, rs7671167 FAM13A variants confer a protective effect on COPD (both P < 0.002, OR < 0.405).
|
26310313 |
2015 |
|
rs7671167
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Statistical analysis revealed that SNP rs7671167 was associated with COPD in former smokers with adjusted P-value of 0.026.
|
23891779 |
2013 |
|
rs7671167
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).
|
22461431 |
2012 |
|
rs2869967
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The FAM13A rs2869967 was associated with COPD (minor CC genotype: P = 0.0007, OR = 2.414).
|
26310313 |
2015 |
|
rs2869967
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Significant differences in genotypic distributions (χ(2)=6.319, p=0.042 for rs2869967</span>; χ(2)=6.062, p=0.048 for rs3821104) and allele distributions (χ(2)=4.014, p=0.045 for rs2869967; χ(2)=5.607, p=0.018 for rs3821104) were observed between patients and control subjects for variants rs2869967 and rs3821104, whereas no statistically significant associations for genotypic and allelic distribution between IREB2 rs2568494 and COPD phenotype (p>0.05) were identified.
|
22027142 |
2011 |
|
rs1903003
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The rs1903003, rs7671167 FAM13A variants confer a protective effect on COPD (both P < 0.002, OR < 0.405).
|
26310313 |
2015 |
|
rs2013701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MPRAs identified multiple functional variants in this region, including rs2013701, a putative COPD-causing variant with allele-specific regulatory activity.
|
30079747 |
2019 |
|
rs17014601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results suggest that the new variant rs17014601 in the <i>FAM13A</i> gene was significantly associated with COPD risk in a Chinese rural population.
|
29872291 |
2018 |
|
rs6830970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs (rs7671167, rs2869966, rs2869967, rs2045517, and rs6830970) were associated with FEV1/FVC ratio in the entire cohort and rs6830970 was associated with FEV1/FVC ratio in COPD cases (P range 0.003-0.034).
|
23891779 |
2013 |