| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.030 | GeneticVariation | BEFREE | Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). | 30916218 | 2019 |
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|
0.030 | GeneticVariation | BEFREE | An association between SLE and the rs1800629 polymorphism was established under the allelic model (allele A vs. allele G; odds ratios [OR] = 2.317), the dominant model (GA+AA vs. GG; OR = 3.214), and the overdominant model (GA vs. AA+GG; OR = 3.494). | 29298134 | 2018 |
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|
0.030 | GeneticVariation | BEFREE | The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations. | 29611038 | 2018 |
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|
0.020 | GeneticVariation | BEFREE | Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). | 30916218 | 2019 |
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|
0.020 | GeneticVariation | BEFREE | The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations. | 29611038 | 2018 |
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|
0.020 | GeneticVariation | BEFREE | Association between TNF promoter -308 G>A and LTA 252 A>G polymorphisms and systemic lupus erythematosus. | 24420856 | 2014 |
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|
0.020 | GeneticVariation | BEFREE | Our results do not support a major role of either the TNF-308 G>A or the LTA 252 A>G polymorphisms as genetic risk factors for SLE. | 21544635 | 2012 |
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|
0.010 | GeneticVariation | BEFREE | Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population. | 29611038 | 2018 |