| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.720 | GeneticVariation | BEFREE | These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci. | 27135738 | 2016 |
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A | 0.720 | GeneticVariation | CLINVAR | Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. | 24563539 | 2014 |
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0.720 | GeneticVariation | BEFREE | As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice. | 24802772 | 2014 |
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|
G | 0.720 | GeneticVariation | CLINVAR | A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. | 23023262 | 2012 |
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A | 0.720 | GeneticVariation | CLINVAR | A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. | 23023262 | 2012 |
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|
0.710 | GeneticVariation | BEFREE | Herein, we identify mutation of EZH2 A677 to a glycine (A677G) among lymphoma cell lines and primary tumor specimens. | 22323599 | 2012 |
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|
C | 0.710 | GeneticVariation | CLINVAR | A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. | 23023262 | 2012 |
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|
G | 0.700 | GeneticVariation | CLINVAR | A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. | 23023262 | 2012 |
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T | 0.700 | GeneticVariation | CLINVAR | A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. | 23023262 | 2012 |