Gene: TP53 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11540652
rs11540652
TP53
0.720 GeneticVariation BEFREE We previously showed that the HSP90 inhibitor ganetespib potently suppresses T-lymphoma initiation and progression and extends overall survival (OS) in hotspot knockin mice expressing the p53 gain-of-function mutants R175H and R248Q (mutp53) by 30-59%. 28300840

2017
dbSNP: rs11540652
rs11540652
TP53
0.720 GeneticVariation BEFREE This was associated with a twofold higher T-lymphoma proliferation in R248Q/- mice compared with G245S/- and null mice. 23538418

2013
dbSNP: rs11540652
rs11540652
TP53
T 0.720 GeneticVariation CLINVAR

dbSNP: rs28934578
rs28934578
TP53
0.010 GeneticVariation BEFREE We previously showed that the HSP90 inhibitor ganetespib potently suppresses T-lymphoma initiation and progression and extends overall survival (OS) in hotspot knockin mice expressing the p53 gain-of-function mutants R175H and R248Q (mutp53) by 30-59%. 28300840

2017
dbSNP: rs879253942
rs879253942
TP53
0.010 GeneticVariation BEFREE The discovery of MYD88 L265P mutations in the vast majority of LPLs has had a major impact on the study of these lymphomas. 26454445

2016
dbSNP: rs867114783
rs867114783
TP53
0.010 GeneticVariation BEFREE TP53(R167H/R167H) mutant pigs primarily developed lymphomas and osteogenic tumors, recapitulating the tumor types observed in mice and humans expressing orthologous TP53 mutant alleles. 25105366

2014
dbSNP: rs1042522
rs1042522
TP53
0.010 GeneticVariation BEFREE Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: "p53", "codon 72" "polymorphism" and "leukemia", or "lymphoma", or "myeloma", thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. 23029260

2012
dbSNP: rs1131691014
rs1131691014
TP53
0.010 GeneticVariation BEFREE Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: "p53", "codon 72" "polymorphism" and "leukemia", or "lymphoma", or "myeloma", thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. 23029260

2012
dbSNP: rs563378859
rs563378859
TP53
0.010 GeneticVariation BEFREE We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3'RR/ p53+/- mice and c-myc-3'RR/Cdk4(R24C) mice represent a spectrum of the same entity. 22592113

2012
dbSNP: rs878854066
rs878854066
TP53
0.010 GeneticVariation BEFREE Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: "p53", "codon 72" "polymorphism" and "leukemia", or "lymphoma", or "myeloma", thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. 23029260

2012
dbSNP: rs1555525126
rs1555525126
TP53
0.010 GeneticVariation BEFREE PCR-SSCP and direct DNA sequencing of exons 2 to 14 of p73 revealed a missense mutation in one primary lymphoma: a G-to-A transition, with Glu291Lys change. 11461077

2001