|
rs2073342
|
|
|
0.020 |
GeneticVariation |
BEFREE |
RNASE3 (ECP) has been identified as an inhibitor of Plasmodium parasites growth in vitro, and genetic analysis in hospitalized Ghanaian subjects has revealed the RNASE3 +371G/C (rs2073342) polymorphism as a susceptibility factor for cerebral malaria.
|
29402293 |
2018 |
|
rs2073342
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The 371G allele of RNASE3 is associated with susceptibility to CM and forms part of a risk associated haplotype GGA defined by the markers: rs2073342 (G-allele), rs2233860 (G-allele) and rs8019343 (A-allele) respectively.
|
22216286 |
2011 |
|
rs895819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the relationship of microRNA SNP to cerebral malaria outcome, we performed TaqMan Genotyping Assays in 110 cerebral malaria and 207 uncomplicated malaria cases for three candidate microRNA SNPs (rs895819 of microRNA-27a, rs57095329 and rs2910164 of microRNA-146a).
|
30599464 |
2019 |
|
rs1041867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three novel (rs914142, rs12626750, and rs1041867) and one previously published (Chr21:34696785 [C > G]) IFNAR1 variants to be associated with CM.
|
29637882 |
2018 |
|
rs12626750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we examined these variants in an expression quantitative trait loci database and found that a protective variant, rs914142, is associated with lower expression of IFNAR1, whereas the CM-associated variant rs12626750 was associated with increased IFNAR1 expression, suggesting that activation of the type I IFN pathway may contribute to pathogenesis of CM.
|
29637882 |
2018 |
|
rs914142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we examined these variants in an expression quantitative trait loci database and found that a protective variant, rs914142, is associated with lower expression of IFNAR1, whereas the CM-associated variant rs12626750 was associated with increased IFNAR1 expression, suggesting that activation of the type I IFN pathway may contribute to pathogenesis of CM.
|
29637882 |
2018 |
|
rs1012356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs of IL22, rs1012356 (P = 0.016, OR = 2.12) and rs2227476 (P = 0.007, OR = 2.08) were independently associated with CM in a sample of 115 Nigerian children with CM and 160 controls.
|
28139719 |
2017 |
|
rs2227473
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2227473, in linkage disequilibrium with rs2227476, was also associated with CM in the combined cohort for these two populations, (P = 0.004, OR = 1.55).
|
28139719 |
2017 |
|
rs2227476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2227473, in linkage disequilibrium with rs2227476, was also associated with CM in the combined cohort for these two populations, (P = 0.004, OR = 1.55).
|
28139719 |
2017 |
|
rs12159217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study involving 115 Nigerian children with CM and 160 controls from the community (CC) showed that IL17F reference single nucleotide polymorphism (SNP) 6913472 (rs6913472) (P = 0.004; odds ratio [OR] = 3.12), IL17F rs4715291 (P = 0.004; OR = 2.82), IL17RA rs12159217 (P = 0.01; OR = 2.27), and IL17RA rs41396547 (P = 0.026; OR = 3.15) were independently associated with CM.
|
26667835 |
2016 |
|
rs41396547
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that one additional SNP, IL17RA rs41433045, in linkage disequilibrium (LD) with rs41396547, was associated with CM in both Nigeria and Mali (P = 0.002; OR = 4.12 in the combined sample).
|
26667835 |
2016 |
|
rs41433045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that one additional SNP, IL17RA rs41433045, in linkage disequilibrium (LD) with rs41396547, was associated with CM in both Nigeria and Mali (P = 0.002; OR = 4.12 in the combined sample).
|
26667835 |
2016 |
|
rs4715291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study involving 115 Nigerian children with CM and 160 controls from the community (CC) showed that IL17F reference single nucleotide polymorphism (SNP) 6913472 (rs6913472) (P = 0.004; odds ratio [OR] = 3.12), IL17F rs4715291 (P = 0.004; OR = 2.82), IL17RA rs12159217 (P = 0.01; OR = 2.27), and IL17RA rs41396547 (P = 0.026; OR = 3.15) were independently associated with CM.
|
26667835 |
2016 |
|
rs6913472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study involving 115 Nigerian children with CM and 160 controls from the community (CC) showed that IL17F reference single nucleotide polymorphism (SNP) 6913472 (rs6913472) (P = 0.004; odds ratio [OR] = 3.12), IL17F rs4715291 (P = 0.004; OR = 2.82), IL17RA rs12159217 (P = 0.01; OR = 2.27), and IL17RA rs41396547 (P = 0.026; OR = 3.15) were independently associated with CM.
|
26667835 |
2016 |
|
rs12912082
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The THBS1 haplotype CCCCA (rs1478604, rs7170682, rs2664141, rs12912082, rs3743125) was a risk factor in the endemic region (relative risk = 3.78) and an ESEL SNP (rs5368, His468Tyr) associated with cerebral malaria (CM) [CM vs. non-cerebral malaria (NCM), odds ratio (OR) = 2.23, p = 0.03].
|
26194693 |
2015 |
|
rs1478604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The THBS1 haplotype CCCCA (rs1478604, rs7170682, rs2664141, rs12912082, rs3743125) was a risk factor in the endemic region (relative risk = 3.78) and an ESEL SNP (rs5368, His468Tyr) associated with cerebral malaria (CM) [CM vs. non-cerebral malaria (NCM), odds ratio (OR) = 2.23, p = 0.03].
|
26194693 |
2015 |
|
rs2664141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The THBS1 haplotype CCCCA (rs1478604, rs7170682, rs2664141, rs12912082, rs3743125) was a risk factor in the endemic region (relative risk = 3.78) and an ESEL SNP (rs5368, His468Tyr) associated with cerebral malaria (CM) [CM vs. non-cerebral malaria (NCM), odds ratio (OR) = 2.23, p = 0.03].
|
26194693 |
2015 |
|
rs3743125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The THBS1 haplotype CCCCA (rs1478604, rs7170682, rs2664141, rs12912082, rs3743125) was a risk factor in the endemic region (relative risk = 3.78) and an ESEL SNP (rs5368, His468Tyr) associated with cerebral malaria (CM) [CM vs. non-cerebral malaria (NCM), odds ratio (OR) = 2.23, p = 0.03].
|
26194693 |
2015 |
|
rs5368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The THBS1 haplotype CCCCA (rs1478604, rs7170682, rs2664141, rs12912082, rs3743125) was a risk factor in the endemic region (relative risk = 3.78) and an ESEL SNP (rs5368, His468Tyr) associated with cerebral malaria (CM) [CM vs. non-cerebral malaria (NCM), odds ratio (OR) = 2.23, p = 0.03].
|
26194693 |
2015 |
|
rs6505469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conversely, NOS2 cistronic variants (namely, rs6505469) operate in infected individuals to increase NO bioavailability and confer increased susceptibility to unapparent infection but protect from cerebral malaria.
|
24379293 |
2014 |
|
rs139262191
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the IFNB1 variant, p.Ser34Arg, might be a risk factor for cerebral malaria in Indian populations.
|
23333334 |
2013 |
|
rs1418646618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the IFNB1 variant, p.Ser34Arg, might be a risk factor for cerebral malaria in Indian populations.
|
23333334 |
2013 |
|
rs4508917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Following extensive bioinformatics analyses, two reported single nucleotide polymorphisms in the CXCL10 promoter (-135G>A [rs56061981] and -1447A>G [rs4508917]) were identified among 66 CM and 69 non-CM Indian patients using PCR-restriction fragment length polymorphism assay.
|
24349056 |
2013 |
|
rs56061981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Following extensive bioinformatics analyses, two reported single nucleotide polymorphisms in the CXCL10 promoter (-135G>A [rs56061981] and -1447A>G [rs4508917]) were identified among 66 CM and 69 non-CM Indian patients using PCR-restriction fragment length polymorphism assay.
|
24349056 |
2013 |
|
rs2233860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The 371G allele of RNASE3 is associated with susceptibility to CM and forms part of a risk associated haplotype GGA defined by the markers: rs2073342 (G-allele), rs2233860 (G-allele) and rs8019343 (A-allele) respectively.
|
22216286 |
2011 |