rs1057519695
|
|
CC |
0.800 |
CausalMutation |
CLINVAR |
First-in-human, phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of RO5126766, a first-in-class dual MEK/RAF inhibitor in patients with solid tumors.
|
22761467 |
2012 |
rs1057519695
|
|
CA |
0.800 |
CausalMutation |
CLINVAR |
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
|
18390968 |
2008 |
rs1057519695
|
|
CC |
0.800 |
CausalMutation |
CLINVAR |
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
|
23614898 |
2013 |
rs1057519695
|
|
CC |
0.800 |
CausalMutation |
CLINVAR |
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
|
20179705 |
2010 |
rs1057519695
|
|
CC |
0.800 |
CausalMutation |
CLINVAR |
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
|
20130576 |
2010 |
rs11554290
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs11554290
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
|
20179705 |
2010 |
rs11554290
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma.
|
23569304 |
2013 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
|
20130576 |
2010 |
rs11554290
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
|
21107323 |
2010 |
rs11554290
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
|
18390968 |
2008 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
|
20179705 |
2010 |
rs11554290
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
NRAS-mutant melanoma: response to chemotherapy.
|
21576590 |
2011 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
Distinct sets of genetic alterations in melanoma.
|
16291983 |
2005 |
rs11554290
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
|
23614898 |
2013 |
rs11554290
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
|
20179705 |
2010 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
Ras mutations in human melanoma: a marker of malignant progression.
|
8120410 |
1994 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma.
|
23538902 |
2013 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
|
23414587 |
2013 |
rs11554290
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
First-in-human, phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of RO5126766, a first-in-class dual MEK/RAF inhibitor in patients with solid tumors.
|
22761467 |
2012 |
rs11554290
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Distinct sets of genetic alterations in melanoma.
|
16291983 |
2005 |
rs11554290
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
NRAS-mutant melanoma: response to chemotherapy.
|
21576590 |
2011 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
|
2674680 |
1989 |
rs11554290
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.
|
20406486 |
2010 |
rs11554290
|
|
G |
0.800 |
CausalMutation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |