|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers.
|
30122193 |
2018 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was also no significant relationship between dyslipoproteinemia or obesity and the PPARgamma2 Pro12Ala genotype.
|
9918859 |
1999 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations.
|
17439324 |
2007 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%.
|
27442659 |
2016 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism.
|
16050954 |
2005 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m2) nondiabetic subjects.
|
16231017 |
2006 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
|
28090739 |
2017 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9.
|
10873398 |
2000 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Concurrently, genotyping of the Pro12Ala polymorphism showed that obese subjects possess a significantly higher frequency of the Pro/Pro genotype than nonobese controls (90.5 vs 79.5%; P = 0.03), suggesting that this genotype is involved in an increased risk of obesity in the Tunisian population.
|
23315125 |
2013 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results showed that the Pro12Ala polymorphism is not associated with childhood or adult obesity in the French Caucasian population.
|
15784141 |
2005 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity.
|
18280041 |
2008 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional single nucleotide polymorphism (SNP) that predicts a proline to alanine substitution (Pro12Ala) within the coding region of this gene has previously been associated with obesity and type 2 diabetes in several populations.
|
12829658 |
2003 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association.
|
22410809 |
2012 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the higher frequency of the C-->T substitution in exon 6 of the PPAR-gamma gene in PCOS women suggests that it plays a role in the complex pathogenetic mechanism of obesity in PCOS, whereas the Pro(12)Ala polymorphism does not seem to affect BMI in PCOS women.
|
14671186 |
2003 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors.
|
26185753 |
2015 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between PPARγ2 Pro12Ala polymorphism and myocardial infarction and obesity in Han Chinese in Hohhot, China.
|
22653647 |
2012 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.
|
17898990 |
2007 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of the peroxisome proliferator-activated receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus.
|
25928419 |
2015 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PPARG rs1801282 SNP did not exhibit any significant association with obesity among the complete sample population.
|
25182148 |
2015 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.
|
11158005 |
2001 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that P12A may be a genetic marker indicating risk for obesity persisting into adolescence.
|
11591408 |
2001 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity.
|
24969838 |
2014 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of the C1431T silent mutation and the Pro12Ala missense transversion within the PPARgamma gene with the development of T2DM or obesity has often yielded contradictory results.
|
18250615 |
2007 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis.
|
26361038 |
2015 |