|
rs11208659
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
|
rs11208659
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
|
rs193922650
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001).
|
29893028 |
2018 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity.
|
29893028 |
2018 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As regards, rs7799039 AA genotype showed significant higher leptin level than other genotypes in the same group with a non-significant difference in genotypes distribution between obese and controls. rs1137101 variant of leptin receptor and fasting leptin level are correlated with overweight and obesity in Saudi children.
|
29412799 |
2018 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
LEPR rs1137101 GG genotype was related to reduced risk of obesity (odds ratio [OR] 0.26, 95% confidence interval [CI] 0.08-0.79; p = 0.018) and MetS (OR 0.36, 95% CI 0.15-0.88; p = 0.024), but it was not significant after Bonferroni correction for multiple tests as compared to the AA genotype (p > 0.01).
|
28975585 |
2018 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between overweight/obesity and polymorphisms in the LEP (rs7799039), LEP receptor (LEPR; rs1137101), and ADIPOQ genes (rs2241766, rs1501299) with the response to breast cancer treatment in Mexican women.
|
28416193 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we hypothesized that the LEP-rs7799039 and LEPR-rs1137101 SNPs are related to the risk of pre-pregnancy overweight/obesity (body mass index ≥25 kg/m<sup>2</sup>) as well as to excessive gestational weight gain (GWG) and high concentrations of leptin throughout pregnancy.
|
29241578 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of two obesity-related gene polymorphisms LEPG2548A rs7799039 and LEPRQ223R rs1137101 with the risk of breast cancer.
|
28938640 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the impact of mothers' and newborns' fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother-newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029).
|
27930556 |
2016 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others.
|
26064921 |
2015 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (p = 0.002) and 4.1 times higher risk of hypercholesterolemia (p = 0.001).
|
26365669 |
2015 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity.
|
26255942 |
2015 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, our data suggest that a combination of polymorphism in the LEP gene 3' flanking region, and Lys109Arg, Lys656Asn variants in LEPR gene is associated with obesity in Chinese Han population.
|
24308887 |
2013 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the LEPR gene Q223R polymorphism has an association with waist and hip circumferences in obese group but no direct association with obesity although there is a significant influence on lipid profile both in obese and non-obese subjects.
|
23954230 |
2013 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the LEP G2548A polymorphism is not a relevant obesity marker and that the LEPR 668A/G polymorphism may be related to obesity in a Turkish population.
|
24319309 |
2013 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allele dosage analysis of rs2069845, rs1137100, and rs3801266 revealed that children with five to six risk alleles had an approximately four times increased risk of obesity than children with less than two risk alleles (P = 1.2 × 10(-7)).
|
22228719 |
2012 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study evaluated the association between obesity and the K109R, Q223R, and K656N polymorphisms of the leptin receptor (LEPR) locus.
|
22746211 |
2012 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study showed that LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
|
22734460 |
2012 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects.
|
22028824 |
2011 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that c.517A→G and Lys(109)Arg contribute to the variation in anthropometric obesity phenotype indicators observed among Black African and mixed-ancestry South African learners.
|
21921635 |
2011 |