|
rs1049353
|
|
|
0.050 |
GeneticVariation |
BEFREE |
G1359A Variant of the Cannabinoid Receptor Gene (rs1049353) and Obesity-Related Traits and Related Endophenotypes: A Meta-Analysis.
|
30016776 |
2018 |
|
rs1049353
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the allelic distribution of polymorphism (G1359A) of the CB1 receptor gene in a geographical area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients.
|
25682784 |
2016 |
|
rs1049353
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No significant difference was found between genotypes and alleles of DRD2 Taq1A and DRD2 Taq1B polymorphism in patients and controls, while the CNR1 receptor 1359G/A polymorphism and the presence of the A allele may be one risk factor for susceptibility to obesity.
|
23057570 |
2012 |
|
rs1049353
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Previous studies demonstrated that G1359A polymorphism of cannabinoid receptor-1 (CNR1) was associated with cardiovascular risk factors including obesity, insulin resistance, dyslipidemia, and inflammation, which are also risk factors for developing type 2 diabetes mellitus (T2DM).
|
22138970 |
2012 |
|
rs1049353
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We therefore genotyped this SNP in 235 independent German obesity families (at least two obese sibs and both parents) and in parallel screened the CNR1 coding region for sequence variations in 120 German extremely obese children and adolescents who mainly contributed to the initial trend observed for rs1049353.
|
17292652 |
2007 |
|
rs2023239
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |
|
rs2023239
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Neither rs2023239 nor rs806381 polymorphism was significantly associated with body mass index-defined overweight and obesity or waist-to-hip-ratio-defined obesity.
|
22244745 |
2012 |
|
rs806381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs2023239 nor rs806381 polymorphism was significantly associated with body mass index-defined overweight and obesity or waist-to-hip-ratio-defined obesity.
|
22244745 |
2012 |
|
rs9444584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |
|
rs9450898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, rs9444584 is in strong linkage disequilibrium with two other SNPs (rs9450898 (r(2) = 0.841) and rs2023239 (r(2) = 0.920)) that have been associated with addiction, obesity (rs2023239), and reduced fronto-temporal white matter volumes in schizophrenia patients as a result of cannabis misuse (rs9450898).
|
22362764 |
2012 |
|
rs806368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control study of lean (BMI <25 kg/m(2)) versus obese (BMI >30 kg/m(2)) subjects, rs806368 was found to be nominally associated with obesity in the Sorbian cohort (adjusted p < 0.05), but not in the Leipzig cohort.
|
20415562 |
2010 |