|
rs1544410
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of candidate gene single nucleotide polymorphisms (SNPs), namely FTO (rs9939609) and VDR (rs1544410), with obesity in the UAE population.
|
29343214 |
2018 |
|
rs1544410
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance.
|
28617856 |
2017 |
|
rs1544410
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results showed that the VDR SNPs rs731236 (G) (TaqI) and rs1544410 (T) (Bsm-I) minor allele polymorphisms are significantly more frequent in obese individuals (p = 0.009, β = 0.086 and p = 0.028, β = 0.072, respectively).
|
25020064 |
2014 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results showed that the VDR SNPs rs731236 (G) (TaqI) and rs1544410 (T) (Bsm-I) minor allele polymorphisms are significantly more frequent in obese individuals (p = 0.009, β = 0.086 and p = 0.028, β = 0.072, respectively).
|
25020064 |
2014 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Analysis of vitamin D receptor (VDR) TaqI (rs731236; T/C) and fat mass and obesity-associated (FTO) (rs9939609; A/T) [corrected] polymorphisms in 82 obesity subjects and 102 controls showed significant association for VDR TaqI 'T' allele and obesity (OR: 2.07; 1.123-3.816; P=0.019), contributing to an elevated BMI of 3kg/m(2) per risk allele.
|
23103831 |
2013 |
|
rs3847987
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele C of rs3847987 was risk factors for obesity (P = 0.006).
|
31813936 |
2020 |
|
rs12721377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, polymorphisms in the GC (rs2282679, rs4588, rs7041) and VDR (rs12721377) genes were independently associated with obesity and 25OHD3 levels with a clear sex dimorphism.
|
26881316 |
2016 |
|
rs3782905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The VDR SNP, rs3782905, was significantly associated with obesity (P=0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group.
|
25517289 |
2015 |
|
rs2239179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interactions between two previously studied VDR polymorphisms (rs7968585 and rs2239179) and 25OHD concentrations on metabolic and cardiovascular disease-related outcomes such as obesity- (body mass index, waist circumference, waist-hip ratio (WHR)), cardiovascular- (systolic and diastolic blood pressure), lipid- (high- and low-density lipoprotein, triglycerides, total cholesterol), inflammatory- (C-reactive protein, fibrinogen, insulin growth factor-1, tissue plasminogen activator) and diabetes- (glycated haemoglobin) related markers were examined in the 1958 British Birth cohort (n up to 5160).
|
24582179 |
2014 |
|
rs2239185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |