|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There was no significant difference in TLR4 + 3725 G/C and Asp299Gly genotype frequencies between non-peptic ulcer (NPUD) and peptic ulcer (PUD) individuals in the context of peptic ulcer development and susceptibility to infection with H. pylori.
|
29135054 |
2018 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No significant differences were found among the PU, AS, and NHS groups regarding the genetic differences at rs4986790 in the TLR4 gene.
|
29755012 |
2018 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We observed that the individuals harboring heterozygous and homozygous polymorphic variants of TLR4 conferred a significant risk to develop chronic H. pylori infection and peptic ulcer disease [rs4986790 AG, p=0.001, OR-2.7, 95%CI: 1.5-5.03; GG, p=0.0006, OR-9.8, 95%CI: 2.4-39.4; rs4986791CT, p=0.0001, OR-7.2, 95%CI: 3.7-7.2; TT, p=0.0001, OR-7.9, 95%CI: 2.6-23.7].
|
27993530 |
2017 |
|
rs3842787
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Individuals with two single nucleotide polymorphisms (SNPs) of cyclooxygenase-1 (COX-1), A-842G and C50T, exhibit increased sensitivity to aspirin and lower prostaglandin synthesis capacity but the polymorphism lacked statistical significance in relation to an association with bleeding peptic ulcer.
|
26369686 |
2015 |
|
rs1045642
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU.
|
24815441 |
2014 |
|
rs1045642
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The isolated C3435T ABCB1 SNP is not a major factor for genetic susceptibility to peptic ulcer, but in a group of men who suffered from peptic ulcer, this polymorphism seemed to be a risk factor for H. pylori infection development.
|
22001987 |
2011 |
|
rs3842787
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNP) of cyclooxygenase-1 (COX-1), A-842G and C50T, exhibited increased sensitivity to aspirin and had lower prostaglandin synthesis capacity, lacking statistical significance in the association with bleeding peptic ulcer.
|
20586862 |
2010 |
|
rs1045642
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this preliminary data, the association with MDR1 C3435T polymorphism and risk for developing H. pylori-related gastric cancer and peptic ulcer in Japanese was low.
|
18644389 |
2008 |
|
rs3842787
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The adjusted risk for peptic ulcer bleeding among individuals who were </span>heterozygote for the A-842G/C50T polymorphism was 0.75 (range, 0.19-3.01) compared with wild type.
|
17078001 |
2006 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One hundred and fifty-five patients with upper gastrointestinal diseases (76 peptic ulcer and 79 non-cardia gastric cancer) and 152 matched controls were genotyped for PPAR-γ gene polymorphism (Pro12Ala) by the PCR-RFLP method.
|
20568969 |
2010 |
|
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One hundred and fifty-five patients with upper gastrointestinal diseases (76 peptic ulcer and 79 non-cardia gastric cancer) and 152 matched controls were genotyped for PPAR-γ gene polymorphism (Pro12Ala) by the PCR-RFLP method.
|
20568969 |
2010 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.
|
18372284 |
2008 |
|
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.
|
18372284 |
2008 |
|
rs2723176
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype GG and allele G at IL-37 rs3811047 SNP, and the genotype CC and allele C at IL-37 rs2723176 SNP more frequently expressed in PU patients than total healthy subjects (AS + NHC groups) and were associated with an increased risk of PU development (genotype GG: RR = 3.08, P < 0.009; allele G: RR = 2.94, P < 0.01; genotype CC: RR = 5, P < 0.01; and allele C: RR = 5.0, P < 0.02, respectively).
|
31751903 |
2020 |
|
rs3811047
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype GG and allele G at IL-37 rs3811047 SNP, and the genotype CC and allele C at IL-37 rs2723176 SNP more frequently expressed in PU patients than total healthy subjects (AS + NHC groups) and were associated with an increased risk of PU development (genotype GG: RR = 3.08, P < 0.009; allele G: RR = 2.94, P < 0.01; genotype CC: RR = 5, P < 0.01; and allele C: RR = 5.0, P < 0.02, respectively).
|
31751903 |
2020 |
|
rs1929992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1929992-related GG genotype and G allele may be associated with PU development.
|
31491552 |
2019 |
|
rs4244285
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP2C19*2 polymorphism (rs4244285) changing the CYP2C19 function could be relevant in the predisposition to peptic ulcer disease.
|
30826566 |
2019 |
|
rs121917864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings showed that TLR2 Arg677Trp polymorphism and H. pylori infection may play crucial roles in peptic ulcer development respectively in north of Iran.
|
28844484 |
2018 |
|
rs3761548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype and A allele at rs3761548 could represent a risk factor for PU development.
|
29938865 |
2018 |
|
rs3804099
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results provide evidence regarding the association of the rs3804099 in the TLR2 gene with H. pylori infection and PU.
|
29755012 |
2018 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that TLR4 Thr399Ile polymorphism along with H. pylori infection may play critical roles in peptic ulcer development in North of Iran.
|
29135054 |
2018 |
|
rs5743708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR2 Arg677Trp but not TLR2 -196 to -174 ins/del and Arg753Gln polymorphism alter the risk of peptic ulcer in north of Iran.
|
28844484 |
2018 |
|
rs2231142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the participation of polymorphism at position C421A and mRNA expression of the ABCG2 gene in the development of peptic ulcers, which is a very common and severe disease.
|
26578453 |
2016 |
|
rs55752064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with two single nucleotide polymorphisms (SNPs) of cyclooxygenase-1 (COX-1), A-842G and C50T, exhibit increased sensitivity to aspirin and lower prostaglandin synthesis capacity but the polymorphism lacked statistical significance in relation to an association with bleeding peptic ulcer.
|
26369686 |
2015 |
|
rs1799964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TNFA-308G>A (rs1800629) and TNFA-1031T>C (rs1799964), which are responsible for increased TNFA transcription, could influence the risk of peptic ulceration.
|
25368751 |
2014 |