|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Schizophrenia risk-associated polymorphisms [non-synonymous SNPs rs821616 (Cys704Ser) and rs6675281 (Leu607Phe), and rs821597] were associated with the expression of Delta3 and Delta7Delta8.
|
19805229 |
2009 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.
|
30286368 |
2018 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional GM in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia.
|
22516458 |
2012 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
When haplotypes were constructed with two, three, and four markers, a number of haplotype combinations, especially those including rs821616 and rs821597, were significantly associated with schi</span>zophrenia.
|
17286247 |
2007 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The strongest association is with a haplotype of SNPs rs751229 and rs3738401, located at the 5' end of the gene; the C-A haplotype of these SNPs is associated with a relative risk of schizophrenia of 5 in our population.
|
16389590 |
2006 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition, we confirm that two common structural variants (Q264R and S704C) elevate the risk for schizophrenia slightly (odds ratio 1.3, 95% CI: 1.0-1.7).
|
18164685 |
2008 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Both rs3738401 and rs821616 showed not significantly association with schizophrenia in the Caucasian, Asian, Japanese or Han Chinese populations.
|
29410289 |
2018 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To examine any association between DISC1 and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls.
|
17997036 |
2008 |
|
rs1538979
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirm the SNP interplay effect between rs1538979 and rs821633 that significantly conferred disease risk in male patients with schizophrenia (P = 0.016, OR 1.57).
|
19414483 |
2009 |
|
rs1538979
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, there was an effect of SNP rs1538979 in the pre/postcentral gyrus with decreased activation in healthy controls and increased activation in patients with schizophrenia.
|
21376542 |
2011 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor.
|
30252773 |
2018 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs764901021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The two adjacent polymorphisms displayed a nominally significant association with schizophrenia (IVS2+ 1587G>A, p = .014; 396T<A or Asp123Glu, p = .024).
|
15522253 |
2004 |
|
rs764901021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia.
|
17374448 |
2007 |
|
rs821633
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirm the SNP interplay effect between rs1538979 and rs821633 that significantly conferred disease risk in male patients with schizophrenia (P = 0.016, OR 1.57).
|
19414483 |
2009 |
|
rs821633
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Three risk variants (rs1538979, rs821577, and rs821633) in the Disrupted-in-Schizophrenia-1 (DISC1) gene have previously been associated with both schizophrenia and bipolar disorder in a recent collaborative analysis of European cohorts.
|
21376542 |
2011 |
|
rs11122324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention.
|
30976040 |
2019 |
|
rs1322784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, evidence for association to Asperger syndrome was observed with an intragenic single nucleotide polymorphism (SNP) of DISC1 (rs1322784; P=0.0058), as well as with a three-SNP haplotype (P=0.0013) overlapping the HEP3 haplotype, that was previously observed to associate with schizophrenia in Finnish families.
|
17579608 |
2008 |
|
rs17817356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs2255340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study was to investigate the association of three single-nucleotide polymorphisms (SNPs; rs6675281, rs2255340, and rs2738864) with schizophrenia disorder.
|
30324622 |
2018 |
|
rs2738864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data revealed that the three SNPs are significantly associated with schizophrenia (rs2255349 C>T: confidence interval (CI), 2.115 to 3.268; P = 0.0000 OR: 2.629; rs2738864 C>T: CI, 1.538 to 2.339; P = 0.0000 OR: 1.897; rs6675281 C>T: CI, 2.788 to 4.662; P = 0.0009241 OR: 3.605).
|
30324622 |
2018 |
|
rs2793091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention.
|
30976040 |
2019 |
|
rs2793092
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T/T genotype of rs2793092 SNP in DISC1 was significantly associated with increased LV volume.
|
19913623 |
2010 |