|
rs7341475
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In conclusion, there was only association between the RELN rs7341475 variant and schiz</span>ophrenia in the female gender in a Turkish population.
|
30980267 |
2019 |
|
rs7341475
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01).
|
28506622 |
2017 |
|
rs7341475
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Subgroup analysis indicates that the association between rs7341475 and SZ is only significant in Caucasian.
|
26455866 |
2015 |
|
rs7341475
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In addition, we tested the association between variation in RELN expression and rs7341475, an intronic SNP that was found to be associated with schizophrenia in women.
|
21603580 |
2011 |
|
rs7341475
|
|
|
0.860 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case--control study specifically in women by Shifman et al.
|
20431428 |
2010 |
|
rs7341475
|
|
|
0.860 |
GeneticVariation |
BEFREE |
This study does not suggest a significant impact of rs7341475 on brain structure, function, and RELN expression, arguing that this single nucleotide polymorphism and others linked with it do not affect brain measures related to the biology of schizophrenia.
|
20434133 |
2010 |
|
rs7341475
|
|
G |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.
|
18282107 |
2008 |
|
rs7341475
|
|
G |
0.860 |
GeneticVariation |
GWASDB |
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.
|
18282107 |
2008 |
|
rs362746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis revealed that after Bonferroni correction, rs362746 was associated with schizophrenia under the recessive model (P = 0.001) and codominant model (P = 0.003) in the overall group.
|
31469785 |
2019 |
|
rs362814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> A 4-SNP haplotype consisting of rs362814, rs39339, rs540058, and rs661575 was found to be significantly associated with SZ even after Bonferroni correction (χ<sup>2</sup> = 29.024, <i>p</i> = 6.42E-04, <i>p</i><sub>Bonf</sub> = 0.017), and the T-C-T-C haplotype was a protective factor for SZ (OR = 0.050, 95% CI = 0.004-0.705).
|
30891068 |
2019 |
|
rs39339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> A 4-SNP haplotype consisting of rs362814, rs39339, rs540058, and rs661575 was found to be significantly associated with SZ even after Bonferroni correction (χ<sup>2</sup> = 29.024, <i>p</i> = 6.42E-04, <i>p</i><sub>Bonf</sub> = 0.017), and the T-C-T-C haplotype was a protective factor for SZ (OR = 0.050, 95% CI = 0.004-0.705).
|
30891068 |
2019 |
|
rs540058
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> A 4-SNP haplotype consisting of rs362814, rs39339, rs540058, and rs661575 was found to be significantly associated with SZ even after Bonferroni correction (χ<sup>2</sup> = 29.024, <i>p</i> = 6.42E-04, <i>p</i><sub>Bonf</sub> = 0.017), and the T-C-T-C haplotype was a protective factor for SZ (OR = 0.050, 95% CI = 0.004-0.705).
|
30891068 |
2019 |
|
rs661575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> A 4-SNP haplotype consisting of rs362814, rs39339, rs540058, and rs661575 was found to be significantly associated with SZ even after Bonferroni correction (χ<sup>2</sup> = 29.024, <i>p</i> = 6.42E-04, <i>p</i><sub>Bonf</sub> = 0.017), and the T-C-T-C haplotype was a protective factor for SZ (OR = 0.050, 95% CI = 0.004-0.705).
|
30891068 |
2019 |
|
rs736707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01).
|
28506622 |
2017 |
|
rs761198705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A missense variation c.9575 C > G (p.Thr3192Ser) was identified in RELN, which is known as a risk gene for SCZ, located on chromosome 7q22, in the pedigree.
|
27071546 |
2016 |
|
rs262355
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For rs262355, four studies with 2017 SZ patients and 3274 controls are included, the results demonstrate that carriage of A allele is associated with increased risk of SZ only in Caucasian (dominant model: OR=1.17, 95%CI=1.01-1.37; additive model OR=1.13, 95%CI=1.02-1.27).
|
26455866 |
2015 |
|
rs12705169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was found between rs12705169 and SZ (p=0.001).
|
21549172 |
2011 |
|
rs362719
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that rs362719 of the RELN gene is associated with susceptibility to schizophrenia in Chinese Han, possibly through a gender-specific mechanism.
|
21863557 |
2011 |