|
rs78655421
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we describe a case of a patient with CF (R117H/7 T/F508del) who presented with recurrent pancreatitis who was effectively treated with ivacaftor in the absence of respiratory symptoms.
|
31296159 |
2019 |
|
rs11988997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected five common SNPs (rs11988997, rs379742, rs10273639, rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium.
|
28913878 |
2018 |
|
rs2995271
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected five common SNPs (rs11988997, rs379742, rs10273639, rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium.
|
28913878 |
2018 |
|
rs4751995
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we tested the hypothesis that variant p.W358X might increase risk for chronic pancreatitis through acinar cell stress.
|
30408063 |
2018 |
|
rs9111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>Bach2</i> repression mediates Th17 cell induced inflammation and rs9111-TT in individuals with primary genetic susceptibility to CP is associated with clinical features of advanced disease.
|
29511557 |
2018 |
|
rs12008279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study confirmed a significant association of 2 variants in CLDN2 gene (rs4409525-OR 1.71, P = 1.38 x 10-09; rs12008279-OR 1.56, P = 1.53 x 10-04) and 2 variants in MORC4 gene (rs12688220-OR 1.72, P = 9.20 x 10-09; rs6622126-OR 1.75, P = 4.04x10-05) in Indian patients with CP.
|
26820620 |
2016 |
|
rs13324142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a German replication cohort all exons were sequenced in 40 non-alcoholic CP cases and variant c.616G > A (p.V206M) was further analyzed by sequencing in 321 CP cases and 171 controls.
|
26372434 |
2016 |
|
rs1554499091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that PRSS1 variant p.L104P exhibits a variety of phenotypic changes that can increase risk for chronic pancreatitis.
|
26822915 |
2016 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the mir-146a rs2910164 may contribute to genetic susceptibility to chronic pancreatitis, and that mir-146a might be involved in chronic pancreatitis development.
|
26852168 |
2016 |
|
rs371282890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A Chinese patient with recurrent pancreatitis during pregnancy induced by hypertriglyceridemia associated with compound heterozygosity (Glu242Lys and Leu252VaL) in the lipoprotein lipase gene.
|
26892137 |
2016 |
|
rs4409525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study confirmed a significant association of 2 variants in CLDN2 gene (rs4409525-OR 1.71, P = 1.38 x 10-09; rs12008279-OR 1.56, P = 1.53 x 10-04) and 2 variants in MORC4 gene (rs12688220-OR 1.72, P = 9.20 x 10-09; rs6622126-OR 1.75, P = 4.04x10-05) in Indian patients with CP.
|
26820620 |
2016 |
|
rs6622126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study confirmed a significant association of 2 variants in CLDN2 gene (rs4409525-OR 1.71, P = 1.38 x 10-09; rs12008279-OR 1.56, P = 1.53 x 10-04) and 2 variants in MORC4 gene (rs12688220-OR 1.72, P = 9.20 x 10-09; rs6622126-OR 1.75, P = 4.04x10-05) in Indian patients with CP.
|
26820620 |
2016 |
|
rs761886494
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A Chinese patient with recurrent pancreatitis during pregnancy induced by hypertriglyceridemia associated with compound heterozygosity (Glu242Lys and Leu252VaL) in the lipoprotein lipase gene.
|
26892137 |
2016 |
|
rs773891125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A Chinese patient with recurrent pancreatitis during pregnancy induced by hypertriglyceridemia associated with compound heterozygosity (Glu242Lys and Leu252VaL) in the lipoprotein lipase gene.
|
26892137 |
2016 |
|
rs121913529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
EGFR activation induced expression of NFATc1 in metaplastic areas from patients with chronic pancreatitis and in pancreatic tissue from Kras(G12D) mice.
|
25623042 |
2015 |
|
rs139729994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data suggest that the Japanese-specific CFTR variant L1156F causes mild dysfunction of CFTR and increases the risk of alcoholic chronic pancreatitis in Japanese.
|
26089335 |
2015 |
|
rs11568818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was aimed to investigate the association of MMP-7 -181A/G (rs11568818) gene promoter polymorphism in patients with chronic pancreatitis.
|
25579141 |
2014 |
|
rs1799750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study revealed a significant association of the MMP-1 -1607 1G/2G (rs1799750) gene promoter polymorphism with chronic pancreatitis, and it can be considered a biological marker in the etiology of chronic pancreatitis.
|
23644943 |
2013 |
|
rs762727745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors also observed significant association for the synonymous variant c.180C>T (p.(=)) with CP (OR 2.71, 95% CI 1.79 to 4.12, p=5.3 × 10(-7)).
|
22580415 |
2013 |
|
rs111033566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis.
|
22699143 |
2012 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The absence of an association of PNPLA3 p.I148M with alcoholic CP seems not to point to a common pathway in the development of alcoholic CP and alcoholic liver cirrhosis.
|
22276112 |
2012 |
|
rs980303898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the pancreata of Pdx1-Cre; LSL-Kras(G12D) mice, exendin-4 led to acceleration of the disruption of exocrine architecture and chronic pancreatitis with mucinous metaplasia and increased formation of murine PanIN lesions.
|
22266668 |
2012 |
|
rs747940576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two common haplotypes, c.101A>G (p.N34S) and c.-215G>A, and four intronic alterations of the serine protease inhibitor Kazal type 1 (SPINK1) gene have been found to increase the risk for CP in the Asia Pacific region.
|
21323990 |
2011 |
|
rs1413293653
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Extended analysis of the p.T167A variant revealed no association to CP and in functional assays p.T167A showed normal secretion and activity.
|
20484962 |
2010 |
|
rs142022985
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Extended analysis of the p.T167A variant revealed no association to CP and in functional assays p.T167A showed normal secretion and activity.
|
20484962 |
2010 |