|
rs1229984
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings suggest that rs1229984 at 4q23 and rs671 at 12q24 may serve as candidate markers for susceptibility to HNC in Chinese population.
|
22674868 |
2013 |
|
rs1695
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The variables age ≥ 48 years, smoking and drinking can be predictors for head and neck cancer development; moreover, A313G GSTP1 polymorphism, GSTM1 and GSTT1 null genotypes can modulate the risk for this disease.
|
23661016 |
2013 |
|
rs1799782
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility.
|
24086310 |
2013 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Association of pre-miR-146a rs2910164 polymorphism with the risk of head and neck cancer.
|
23267167 |
2013 |
|
rs1229984
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
|
22500060 |
2012 |
|
rs1695
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis does not support a significant association between the GSTP1 Ile105Val polymorphism and risk of HNC.
|
23144854 |
2012 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested the XRCC3 241M allele (MM+TM) might act as a head and neck cancer risk factor among all subjects, and the effect of T241M polymorphism on head and neck susceptibility should be studied with a larger, stratified population.
|
23244135 |
2012 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There was no association between MTHFR C677T polymorphism and head and neck cancer (p = 0.50).
|
21180947 |
2011 |
|
rs13181
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study.
|
20571908 |
2011 |
|
rs13181
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis demonstrated that XPD Lys751Gln polymorphism could be a prediction marker for risk of head and neck cancer.
|
22179996 |
2011 |
|
rs1229984
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).
|
19887496 |
2010 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population.
|
20804747 |
2010 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C).
|
18789576 |
2009 |
|
rs1799782
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Because of the important role of the XRCC1 gene in DNA repair, we wanted to test the effects of the Arg194Trp and Arg399Gln polymorphisms of XRCC1 on the clinical outcome of head and neck cancer.
|
19846968 |
2009 |
|
rs1695
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The estimated head and neck cancer risk for the combination of either CYP1A1 Ile462Val or CYP1A1 Val462Val genotype with either GSTP1 Ile105Val or Val105Val genotype (OR=2.89, 95% CI: 0.71-11.71) and for the combination of either CYP1A1 Ile462Val or CYP1A1 Val462Val genotype with GSTT1 null genotype (OR=2.62, 95% CI: 0.64-10.85) suggested the absence of the modifying effect of combined variant alleles on head and neck cancer susceptibility.
|
18590468 |
2008 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Pooling data and DNA specimens from three case-control studies in western Washington State, North Carolina, and Puerto Rico, totaling 555 cases (430 whites) and 792 controls (695 whites), we studied the risk of head and neck cancer in relation to common nonsynonymous single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met).
|
16030112 |
2005 |
|
rs1051740
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To evaluate the association between the EPHX1 Tyr113His and His139Arg polymorphisms in the EPHX1 gene and the risk of head and neck cancer.
|
25923690 |
2015 |
|
rs1799793
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We thus conclude that the XPD Asp312Asn and APE1 Asp148Glu polymorphisms increase the risk for HNC in association with smoking and/or tobacco chewing in the population under study.
|
25916209 |
2015 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A comprehensive literature search was conducted to identify all case-control studies of the XRCC1 Arg194Trp and Arg280His polymorphisms in head and neck cancer.
|
25062722 |
2014 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility.
|
24086310 |
2013 |
|
rs1799793
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that XPD Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.
|
22536360 |
2012 |
|
rs1799793
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.
|
20429839 |
2010 |
|
rs1051740
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In addition, increased risk for HNC was associated consistently with the ALDH2*1/*2, p53 codon 72 Pro/Pro and EPHX1 codon 113 Tyr/His and His/His genotypes.
|
18425322 |
2008 |
|
rs1051740
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Combinations of the Y113H and H139R polymorphic EPHX1 variants have been assumed to alter the enzyme activity and thus the risk of squamous cell head and neck cancer (SCCHN).
|
12491039 |
2003 |