|
rs10950641
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs10950641
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs4775319
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs4775319
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs6796803
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs6796803
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs4804217
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was not a risk factor for HNC susceptibility.
|
24694255 |
2014 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Furthermore, the risk of HNC was associated with XRCC1 Arg399Gln polymorphism stratified by occupational exposure status (OR = 2.29; P = 0.024).
|
24020925 |
2014 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility.
|
24086310 |
2013 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Because of the important role of the XRCC1 gene in DNA repair, we wanted to test the effects of the Arg194Trp and Arg399Gln polymorphisms of XRCC1 on the clinical outcome of head and neck cancer.
|
19846968 |
2009 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Pooling data and DNA specimens from three case-control studies in western Washington State, North Carolina, and Puerto Rico, totaling 555 cases (430 whites) and 792 controls (695 whites), we studied the risk of head and neck cancer in relation to common nonsynonymous single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met).
|
16030112 |
2005 |
|
rs1695
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A cost-minimization analysis was planned to compare GSTP1 c.313A>G genotyping versus overall fosaprepitant implementation for patients with head and neck cancer under chemoradiation therapy with high-dose cisplatin.
|
30870506 |
2019 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Variant alleles of miR-146a rs2910164 may have a correlation with increased HNC</span> risk.
|
27901485 |
2017 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that MTHFR C677T polymorphism may not be a risk factor for the developing of HNC.
|
25802478 |
2015 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, the results of the present study suggest that Homozygous TT alleles of MTHFR C677T polymorphism might be a risk factor for HNC among individuals who have a heavy drinking history.
|
26035704 |
2015 |
|
rs1229984
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Alcohol dehydrogenase-1B Arg47His polymorphism is associated with head and neck cancer risk in Asian: a meta-analysis.
|
25323582 |
2015 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Significantly increased risk between microRNA-146a rs2910164 G > C polymorphism and HNC risk were observed in Caucasian population (GC vs. GG: OR = 1.31, 95%CI = 1.01-1.68; GC + CC vs. GG: OR = 1.26, 95%CI = 1.02-1.57).
|
26277865 |
2015 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
miRNA146a rs2910164 C>G polymorphism is not associated with head and neck cancer risk in general, but tehre may be link in Chinese.
|
25987052 |
2015 |
|
rs13181
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, no statistically significant association was observed between the risk of developing HNC and the ERCC2 Lys751Gln and ERCC3 A>G polymorphisms.
|
24020925 |
2014 |
|
rs13181
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There is overall lack of association between XPD Lys751Gln polymorphism and HNC risk under all five genetic models and still no significant association was found in the subgroup analysis by ethnicity and source of controls.
|
24443924 |
2014 |
|
rs1799782
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs1799782
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the XRCC1 Arg194Trp polymorphism is a risk factor for head and neck cancer in Asian populations.
|
25062722 |
2014 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These results further suggested that RAD51 (135G/C, 172 G/T) and XRCC3 (Thr241Met) polymorphisms may be effective biomarkers for genetic susceptibility to HNC.
|
25556492 |
2014 |