Gene: MDM4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2290854
rs2290854
MDM4
A 0.810 GeneticVariation GWASCAT We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 × 10(-8), HR = 1.14, 95% CI: 1.09-1.20). 23544013

2013
dbSNP: rs2290854
rs2290854
MDM4
A 0.810 GeneticVariation GWASDB We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 × 10(-8), HR = 1.14, 95% CI: 1.09-1.20). 23544013

2013
dbSNP: rs2290854
rs2290854
MDM4
0.810 GeneticVariation BEFREE We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 × 10(-8), HR = 1.14, 95% CI: 1.09-1.20). 23544013

2013
dbSNP: rs4245739
rs4245739
MDM4
0.730 GeneticVariation BEFREE However, our study failed to show any relationship between rs4245739 A>C and rs11801299 G>A variants and BC risk (P > .05). 29439926

2018
dbSNP: rs4245739
rs4245739
MDM4
0.730 GeneticVariation BEFREE Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs. 29372105

2017
dbSNP: rs4245739
rs4245739
MDM4
0.730 GeneticVariation GWASCAT Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. 27117709

2016
dbSNP: rs4245739
rs4245739
MDM4
0.730 GeneticVariation BEFREE Interestingly, we observed a combinational effect between MDM4 rs4245739 and P53 Arg72Pro variants in attenuating breast cancer risk, highlighting the importance of the P53 tumor suppressor pathway genes during malignant transformation. 23793604

2013
dbSNP: rs4245739
rs4245739
MDM4
0.730 GeneticVariation GWASCAT Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 23535733

2013
dbSNP: rs1380576
rs1380576
MDM4
0.010 GeneticVariation BEFREE Our findings proposed that the MDM4 rs1380576 C>G polymorphism was a protective factor for BC risk in our population. 29439926

2018
dbSNP: rs116197192
rs116197192
MDM4
0.010 GeneticVariation BEFREE The D153G substitution only partially segregated with breast cancer in the family and was not identified on additional 680 chromosomes screened. 18279506

2008