rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Biochemical analyses of transfected cells and growth inhibition studies with lung cancer cell lines demonstrate that the T790M mutation confers resistance to EGFR mutants usually sensitive to either gefitinib or erlotinib.
|
15737014 |
2005 |
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
|
16258541 |
2005 |
rs1057519847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
EGFR mutations (CTG-->CGG; L858R) were found from 14 of 95 lung cancer patients.
|
16003726 |
2006 |
rs1057519847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
EGFR mutations (CTG; CGG; L858R) were found from 63 of 575 lung cancer patients.
|
16890322 |
2006 |
rs1057519847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two weeks after induction with doxycycline, mice that express the EGFR(L858R) allele show diffuse lung cancer highly reminiscent of human bronchioloalveolar carcinoma and later develop interspersed multifocal adenocarcinomas.
|
16705038 |
2006 |
rs1057519848
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two weeks after induction with doxycycline, mice that express the EGFR(L858R) allele show diffuse lung cancer highly reminiscent of human bronchioloalveolar carcinoma and later develop interspersed multifocal adenocarcinomas.
|
16705038 |
2006 |
rs1057519848
|
|
|
0.100 |
GeneticVariation |
BEFREE |
EGFR mutations (CTG-->CGG; L858R) were found from 14 of 95 lung cancer patients.
|
16003726 |
2006 |
rs1057519848
|
|
|
0.100 |
GeneticVariation |
BEFREE |
EGFR mutations (CTG; CGG; L858R) were found from 63 of 575 lung cancer patients.
|
16890322 |
2006 |
rs121434568
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two weeks after induction with doxycycline, mice that express the EGFR(L858R) allele show diffuse lung cancer highly reminiscent of human bronchioloalveolar carcinoma and later develop interspersed multifocal adenocarcinomas.
|
16705038 |
2006 |
rs121434568
|
|
|
0.100 |
GeneticVariation |
BEFREE |
EGFR mutations (CTG-->CGG; L858R) were found from 14 of 95 lung cancer patients.
|
16003726 |
2006 |
rs121434568
|
|
|
0.100 |
GeneticVariation |
BEFREE |
EGFR mutations (CTG; CGG; L858R) were found from 63 of 575 lung cancer patients.
|
16890322 |
2006 |
rs397517132
|
|
|
0.050 |
GeneticVariation |
BEFREE |
V599E BRAF mutation was uncommon in Japanese lung cancer.
|
16376942 |
2006 |
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HKI-272 is an irreversible EGFR/HER/ErbB inhibitor that has been shown to inhibit the growth of T790M mutant cells in vitro in human lung cancer cell lines and in murine cells transfected with sensitizing EGFR mutations.
|
17671147 |
2007 |
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While they produce dramatic responses in a subset of patients-primarily those with activating EGFR mutations-remissions are typically limited to several months due to acquired drug resistance, frequently associated with the secondary T790M mutation in EGFR.In this issue of Cancer Cell, Li et al. report that an irreversible EGFR kinase inhibitor, HKI-272, had limited activity in a mouse lung cancer model driven by an EGFR mutant harboring T790M and an activating mutation.
|
17613432 |
2007 |
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer.
|
17510392 |
2007 |
rs146795390
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These observations suggest that the germline EGFR V843I mutation might have altered EGFR signaling in the multicentric development of adenocarcinoma, bronchoalveolar carcinoma, and atypical adenomatous hyperplasia and also might have had a role in the development of lung cancer in multiple members of her family.
|
18355544 |
2008 |
rs1408630981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated whether the four polymorphisms (-3444C>T, -1985 G>T, I655A A>G and P1170A C>G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations.
|
19055823 |
2008 |
rs1420841957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer.
|
18478265 |
2008 |
rs377444977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most frequent point mutation (A127T) enhanced lung cancer cell growth, colony formation, focal adhesion formation, and colocalized with Bcl-2 in vitro.
|
18172305 |
2008 |
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The T790M mutation is present in about half of the lung cancer patients with acquired resistance, and reported to act by increasing the affinity of the receptor to adenosine triphosphate, relative to its affinity to TKIs.
|
19096299 |
2009 |
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has been linked to the emergence of the EGFR T790M resistance mutation or amplification of MET.
|
19351834 |
2009 |
rs763317
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Fourteen tag SNPs distributed in EGFR were selected for genotyping and one SNP 8227G>A (rs763317) located in the intron 1 of EGFR was significantly associated with lung cancer (P=0.009).
|
19026460 |
2009 |
rs1276184054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study.
|
19726454 |
2009 |
rs727504256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
E709K and Ins770G as well as L858R appear to be functional mutations based on the use of Ba/F3 cells.
|
19726454 |
2009 |
rs757699239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe how an uncharacterized lung cancer mutation in this JM activation domain (V665M) constitutively activates EGFR by augmenting its capacity to act as an acceptor in the asymmetric dimer.
|
19560417 |
2009 |