Gene: EGFR ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2293347
rs2293347
EGFR
0.010 GeneticVariation BEFREE Compared with the rs2293347 GG genotype, the AA/AG genotypes were associated with a significantly decreased risk of lung cancer (adjusted OR = 0.28, 95% confidence interval [CI]=0.13-0.61, P<0.01). 31518089

2019
dbSNP: rs748491031
rs748491031
EGFR
0.010 GeneticVariation BEFREE We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology. 31207149

2019
dbSNP: rs884225
rs884225
EGFR
0.010 GeneticVariation BEFREE Haplotype analysis of rs2233947 and rs884225 showed that the AA haplotype was associated with a significantly decreased risk of lung cancer (P<0.01). 31518089

2019
dbSNP: rs11543848
rs11543848
EGFR
0.010 GeneticVariation BEFREE In addition, no association was detected between rs712830, rs2072454, and rs11543848 SNPs and lung cancer risk. 30011810

2018
dbSNP: rs148934350
rs148934350
EGFR
0.010 GeneticVariation BEFREE Several reports show that germline mutations in the kinase domain of epidermal growth factor receptor (<i>EGFR</i>) such as R776G, R776H, T790M, V843I and P848L, predispose to develop lung cancer. 30225213

2018
dbSNP: rs2072454
rs2072454
EGFR
0.010 GeneticVariation BEFREE In conclusion, <i>EGFR</i> rs712829, rs2072454 SNPs, and TCCG haplotypes are associated with a risk of lung cancer among Jordanians. 30011810

2018
dbSNP: rs712829
rs712829
EGFR ; LOC105375284
0.010 GeneticVariation BEFREE In conclusion, <i>EGFR</i> rs712829, rs2072454 SNPs, and TCCG haplotypes are associated with a risk of lung cancer among Jordanians. 30011810

2018
dbSNP: rs1057519861
rs1057519861
EGFR ; EGFR-AS1
0.010 GeneticVariation BEFREE Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer. 27913578

2017
dbSNP: rs121913465
rs121913465
EGFR ; EGFR-AS1
0.010 GeneticVariation BEFREE S768I Mutation in EGFR in Patients with Lung Cancer. 27211795

2016
dbSNP: rs149006234
rs149006234
EGFR
0.010 GeneticVariation BEFREE We examined the association between c.309T>G and the prognosis of lung cancer by retrospectively reviewing 453 lung cancer patients. 27228500

2016
dbSNP: rs397517108
rs397517108
EGFR ; EGFR-AS1
0.010 GeneticVariation BEFREE S768I Mutation in EGFR in Patients with Lung Cancer. 27211795

2016
dbSNP: rs1389500636
rs1389500636
EGFR
0.010 GeneticVariation BEFREE Paradoxically, the tumor harbored an activating MAPK1 E322K mutation (allelic fraction 0.13), which predicts ERK activation and erlotinib resistance in EGFR-mutant lung cancer. 26181029

2015
dbSNP: rs6965469
rs6965469
EGFR ; LOC105375284
0.010 GeneticVariation BEFREE The EGFR rs6965469 and rs763317 polymorphisms may be risk factors for lung cancer. 26823874

2015
dbSNP: rs1051753269
rs1051753269
EGFR
0.010 GeneticVariation BEFREE We show that G724S mutant EGFR is oncogenic and that it differs from classic lung cancer derived EGFR mutants in that it is cetuximab responsive in vitro, yet relatively insensitive to small molecule kinase inhibitors. 24894453

2014
dbSNP: rs1171287261
rs1171287261
EGFR
0.010 GeneticVariation BEFREE Of the 13 genotypes, 4 genotypes (G464E, G596R, A598T, and G606R) had not been previously reported in lung cancer. 24297085

2014
dbSNP: rs770443325
rs770443325
EGFR
0.010 GeneticVariation BEFREE However, the frequency of the HIF1A C1772T variant allele was significantly higher in lung cancer patients with TP53 LOH (P = 0.015). 21435097

2011
dbSNP: rs104886026
rs104886026
EGFR
0.010 GeneticVariation BEFREE Recently, to identify genetic factors that modify lung cancer risk, CHRNA5 non-synonymous variant amino acid position 398 (D398N) was identified. 19577767

2010
dbSNP: rs1276184054
rs1276184054
EGFR
0.010 GeneticVariation BEFREE Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study. 19726454

2009
dbSNP: rs727504256
rs727504256
EGFR
0.010 GeneticVariation BEFREE E709K and Ins770G as well as L858R appear to be functional mutations based on the use of Ba/F3 cells. 19726454

2009
dbSNP: rs757699239
rs757699239
EGFR
0.010 GeneticVariation BEFREE We describe how an uncharacterized lung cancer mutation in this JM activation domain (V665M) constitutively activates EGFR by augmenting its capacity to act as an acceptor in the asymmetric dimer. 19560417

2009
dbSNP: rs776375114
rs776375114
EGFR
0.010 GeneticVariation BEFREE Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study. 19726454

2009
dbSNP: rs1408630981
rs1408630981
EGFR
0.010 GeneticVariation BEFREE In this study, we investigated whether the four polymorphisms (-3444C>T, -1985 G>T, I655A A>G and P1170A C>G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations. 19055823

2008
dbSNP: rs1420841957
rs1420841957
EGFR
0.010 GeneticVariation BEFREE A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer. 18478265

2008
dbSNP: rs377444977
rs377444977
EGFR
0.010 GeneticVariation BEFREE The most frequent point mutation (A127T) enhanced lung cancer cell growth, colony formation, focal adhesion formation, and colocalized with Bcl-2 in vitro. 18172305

2008
dbSNP: rs763317
rs763317
EGFR
0.020 GeneticVariation BEFREE The EGFR rs6965469 and rs763317 polymorphisms may be risk factors for lung cancer. 26823874

2015