|
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Join effect of three SNPs (PPP1R13L rs1970764, CD3EAP rs967591, GLTSCR1 rs1035938) on chromosome 19q13.3 showed that the designated haplotype8 (rs 1970764<sup>G</sup>-rs967591<sup>A</sup>-rs1035938<sup>C</sup>) [OR (95% CI)=1.60(1.11-2.32), P/0.012] andhaplotype8 (rs1970764<sup>G</sup>-rs967591<sup>G</sup>-rs1035938<sup>T</sup>) [OR (95% CI)=2.45 (1.17-5.12), P=0.018] were associated with increased risk of lung cancer (adjusted by smoking duration).
|
30128886 |
2018 |
|
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
MDR (multifactor dimensionality reduction) analyses showed that smoking history as main effect and three-way models (smoking duration, 19p13.3-GADD45B rs3783501, 19q13.3-CD3EAP rs967591) (P = 0.001-0.002) indicated statistically significant association with lung cancer risk.
|
28870783 |
2017 |
|
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The common haplotype containing PPP1R13L rs1970764(G), CD3EAP rs967591(A), and CD3EAP rs735482(C) was associated with lung cancer [adjusted OR (95 % CI) = 1.29 (1.03-1.62), P = 0.028].
|
26563375 |
2016 |
|
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A functional variant at 19q13.3, rs967591G>A, is associated with shorter survival of early-stage lung cancer.
|
23775331 |
2013 |
|
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, this study suggests that CD3EAP rs967</span>591 variant allele carriers are at increased susceptibility of lung cancer among nonsmoking Chinese women.
|
23624123 |
2013 |
|
rs967591
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, we found that variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer, but the high-risk diplotype predefined among Caucasians was rare and the diplotype is unlikely to confer lung cancer risk in a Chinese population.
|
22335888 |
2012 |
|
rs3212986
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Conclusion We concluded that in lung cancer patients there is a relationship between tumor stage and rs3212986C>A polymorphism.
|
31245210 |
2019 |
|
rs3212986
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The ERCC1 rs3212986 polymorphism was the most associated with the risk of developing lung cancer, both for low and high radon exposures.
|
31446980 |
2019 |
|
rs3212986
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Particularly stratified by smoking status in cases and controls, A allele of ERCC1 rs3212986 also exhibited an enhanced risk to develop lung cancer in smokers only (P < 0.05).
|
30453383 |
2018 |
|
rs735482
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, we were able to reproduce previously found associations between PPP1R13L and CD3EAP polymorphisms and lung cancer risk in an increased study group, and we found interactions between NFKB1 rs28362491-PPP1R13L rs1970764 and smoking duration and between CD3EAP rs735482 and smoking duration.
|
26563375 |
2016 |
|
rs3212986
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An updated meta-analysis was conducted to explore whether lung cancer risk could be attributed to the following ERCC1 polymorphisms: rs11615 (T>C), rs3212986 (C>A), rs3212961 (A>C), rs3212948 (G>C), rs2298881 (C>A).
|
24841208 |
2014 |
|
rs735482
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We addressed the effects of variants/haplotypes of PPP1R13L rs1970764 and CD3EAP rs967591 and rs735482 on susceptibility of lung cancer among nonsmoking Chinese women.
|
23624123 |
2013 |
|
rs735482
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Both carriers of variant CC genotype [adjusted OR (95% CI)=1.28 (1.02-1.60), P=0.04] and variant C-allele among >20 years' smokers [OR (95% CI)=2.13 (1.24-3.67), P=0.006] for CD3EAP rs735482 were at increased risk of lung cancer.
|
24140460 |
2013 |
|
rs735482
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In order to comprehensively capture common genetic variation in the ERCC1 gene, Caucasian data from the International HapMap project was used to assess linkage disequilibrium and choose four tagSNPs (rs1319052, rs3212955, rs3212948, and rs735482) in the ERCC1 gene to genotype 452 lung cancer cases, 175 H&N cancer cases, and 790 healthy controls.
|
20863778 |
2011 |
|
rs62109563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined data suggest that the sub-region with the strongest association to lung cancer susceptibility might locate to the 23.173kb from PPP1R13L intron8 rs1970764 to rs62109563 3' to CD3EAP.
|
27183913 |
2016 |
|
rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk.
|
24140460 |
2013 |
|
rs4803817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype ERCC2 rs3916874(G) and rs238415(C) [OR (95% CI)=1.26 (1.02-1.57), P=0.03] in block 1 and the haplotype PPP1R13L rs4803817(A), CD3EAP rs1046282(T), rs735482(C), ERCC1 rs3212980(A), rs3212964(G) [OR (95% CI)=3.56 (1.55-8.18), P=0.005] in block 3 were associated with lung cancer risk.
|
24140460 |
2013 |