|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer.
|
28476809 |
2017 |
|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The meta-analysis further confirmed the association between the variant rs1805794G>C and lung cancer</span> risk, that compared with the GG genotype, the carriers of C genotypes had a 1.30-fold risk of cancer (95% CI=1.14-1.49, P=8.49×10(-5)).
|
25771871 |
2014 |
|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The functional polymorphism of NBS1 p.Glu185Gln is associated with an increased risk of lung cancer in Chinese populations: case-control and a meta-analysis.
|
25771871 |
2014 |
|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This meta-analysis supports that there is an association between NBS1 Glu185Gln</span> polym</span>orphism and lung cancer</span> risk.
|
23275190 |
2013 |
|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
These associations were: two SNPs rs1799793 and rs13181 in the ERCC2 gene and lung cancer (recessive model) and rs1805794 in the NBN gene and bladder cancer (dominant model).
|
21864546 |
2012 |
|
rs1805794
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We examined the association between two common NBS1 polymorphisms (Leu34Leu, Gln185Glu) and lung cancer risk in a population-based case-control study in Xuan Wei, China.
|
15921821 |
2005 |
|
rs13312986
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was observed for rs13312986 and rs14448; we only found that the rs2735383CC genotype had a significantly increased risk of lung cancer under a recessive genetic model in the total 1559 cases versus 1679 controls (odds ratio = 1.40, 95% confidence interval = 1.18-1.66, P = 0.0001) when compared with GG or GC genotypes; the rs2735383CC genotype carriers had lower messenger RNA and protein expression levels in tumor tissues than those of other genotypes as quantitative polymerase chain reaction and western blot shown.
|
22114071 |
2012 |
|
rs14448
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was observed for rs13312986 and rs14448; we only found that the rs2735383CC genotype had a significantly increased risk of lung cancer under a recessive genetic model in the total 1559 cases versus 1679 controls (odds ratio = 1.40, 95% confidence interval = 1.18-1.66, P = 0.0001) when compared with GG or GC genotypes; the rs2735383CC genotype carriers had lower messenger RNA and protein expression levels in tumor tissues than those of other genotypes as quantitative polymerase chain reaction and western blot shown.
|
22114071 |
2012 |
|
rs2735383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggested that the rs2735383G>C variation contributes to an increased risk of lung cancer by diminishing gene's expression through binding of microRNA-629 to the polymorphic site in the 3'-UTR of NBS1 gene.
|
22114071 |
2012 |
|
rs1063054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, positive associations were found for rs709816 with bladder cancer (OR(adj) = 4.2, 95% CI: 1.4, 12) and rs1063054 with lung cancer (OR(adj) = 1.6, 95% CI: 1.0, 2.3).
|
20478923 |
2010 |
|
rs709816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, positive associations were found for rs709816 with bladder cancer (OR(adj) = 4.2, 95% CI: 1.4, 12) and rs1063054 with lung cancer (OR(adj) = 1.6, 95% CI: 1.0, 2.3).
|
20478923 |
2010 |