Gene: LRRK2 ×
Source: CURATED ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34637584
rs34637584
LRRK2
A 0.810 CausalMutation CLINVAR Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression. 26251043

2015
dbSNP: rs34637584
rs34637584
LRRK2
0.810 GeneticVariation UNIPROT EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease. 23279440

2013
dbSNP: rs34637584
rs34637584
LRRK2
A 0.810 CausalMutation CLINVAR Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis. 22575234

2012
dbSNP: rs34637584
rs34637584
LRRK2
A 0.810 CausalMutation CLINVAR The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study. 18986508

2008
dbSNP: rs34637584
rs34637584
LRRK2
A 0.810 CausalMutation CLINVAR Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. 15726496

2005
dbSNP: rs34637584
rs34637584
LRRK2
A 0.810 CausalMutation CLINVAR Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. 15680455

2005
dbSNP: rs33939927
rs33939927
LRRK2
0.800 GeneticVariation UNIPROT Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. 29212815

2018
dbSNP: rs34805604
rs34805604
LRRK2
0.800 GeneticVariation UNIPROT Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. 29212815

2018
dbSNP: rs34995376
rs34995376
LRRK2
0.800 GeneticVariation UNIPROT Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. 29212815

2018
dbSNP: rs35801418
rs35801418
LRRK2
0.800 GeneticVariation UNIPROT Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. 29212815

2018
dbSNP: rs35870237
rs35870237
LRRK2
0.800 GeneticVariation UNIPROT Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. 29212815

2018
dbSNP: rs33939927
rs33939927
LRRK2
0.800 GeneticVariation UNIPROT Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. 28720718

2017
dbSNP: rs33939927
rs33939927
LRRK2
0.800 GeneticVariation UNIPROT Structural interface between LRRK2 and 14-3-3 protein. 28202711

2017
dbSNP: rs34805604
rs34805604
LRRK2
0.800 GeneticVariation UNIPROT Structural interface between LRRK2 and 14-3-3 protein. 28202711

2017
dbSNP: rs34805604
rs34805604
LRRK2
0.800 GeneticVariation UNIPROT Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. 28720718

2017
dbSNP: rs34995376
rs34995376
LRRK2
0.800 GeneticVariation UNIPROT Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. 28720718

2017
dbSNP: rs34995376
rs34995376
LRRK2
0.800 GeneticVariation UNIPROT Structural interface between LRRK2 and 14-3-3 protein. 28202711

2017
dbSNP: rs35801418
rs35801418
LRRK2
0.800 GeneticVariation UNIPROT Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. 28720718

2017
dbSNP: rs35801418
rs35801418
LRRK2
0.800 GeneticVariation UNIPROT Structural interface between LRRK2 and 14-3-3 protein. 28202711

2017
dbSNP: rs35870237
rs35870237
LRRK2
0.800 GeneticVariation UNIPROT Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. 28720718

2017
dbSNP: rs35870237
rs35870237
LRRK2
0.800 GeneticVariation UNIPROT Structural interface between LRRK2 and 14-3-3 protein. 28202711

2017
dbSNP: rs33939927
rs33939927
LRRK2
0.800 GeneticVariation UNIPROT Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. 26824392

2016
dbSNP: rs33939927
rs33939927
LRRK2
A 0.800 GeneticVariation CLINVAR The discovery of LRRK2 p.R1441S, a novel mutation for Parkinson's disease, adds to the complexity of a mutational hotspot. 27111571

2016
dbSNP: rs34805604
rs34805604
LRRK2
0.800 GeneticVariation UNIPROT Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. 26824392

2016
dbSNP: rs34995376
rs34995376
LRRK2
0.800 GeneticVariation UNIPROT Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. 26824392

2016