|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS.
|
30482443 |
2019 |
|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
The genetic variants of rs3135506 (G), rs10455872 (A) and rs3798220 (G) have low frequency in our population and reflected no association with CAD.
|
29309886 |
2018 |
|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We confirmed the association of the LPA rs10455872 with CAD in a large sample of Brazilian patients.
|
24776095 |
2014 |
|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Individuals with the G allele of rs10455872, which represents approximately one in seven patients, have a higher risk of CAD than the majority of the population even after treatment with statins; and therefore represent a vulnerable group requiring an alternative medication in addition to statin treatment.
|
23903772 |
2013 |
|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
TaqMan SNP genotyping assays were performed to detect the rs6415084, rs3798220 and rs10455872 genotypes in 517 Chinese Han patients with CAD after PCI.
|
23978127 |
2013 |
|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
In conclusion, heritable contributions of LPA rs10455872 and rs3798220 to Lp(a) cholesterol levels and to angiographic CAD were prospectively assessed in this study.
|
23735648 |
2013 |
|
rs10455872
|
|
|
0.770 |
GeneticVariation |
BEFREE |
It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis.
|
22898070 |
2012 |
|
rs74617384
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We found genome-wide significant evidence for association with CAD at the previously well-established LPA locus (lead variant: rs74617384; OR 1.38 [95% CI 1.26, 1.51], p = 3.2 × 10<sup>-12</sup>) and at 9p21 (lead variant: rs10811652; OR 1.19 [95% CI 1.13, 1.26], p = 6.0 × 10<sup>-11</sup>).
|
30003307 |
2018 |
|
rs41272114
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The LPA null allele (rs41272114) is associated with decreased circulating lipoprotein(a) levels and decreased CAD risk.
|
24925971 |
2014 |
|
rs10755578
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD.
|
23036009 |
2012 |
|
rs7767084
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD.
|
23036009 |
2012 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The genetic variants of rs3135506 (G), rs10455872 (A) and rs3798220 (G) have low frequency in our population and reflected no association with CAD.
|
29309886 |
2018 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Both allelic and genotypic associations of rs964184, rs2895811 and rs3798220 with CAD were significant, regardless of adjustment for covariates of gender, age, hypertension, type 2 diabetes, blood lipid profiles and smoking.
|
26740236 |
2016 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The variant allele of rs379</span>8220 in the apolipoprotein(a) gene (LPA) is used to assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with short alleles of the Kringle IV-2 (KIV-2) copy number variation (CNV) and high lipoprotein(a) (Lp(a)) concentrations.
|
26302166 |
2015 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Rs10455872 strongly predicted prevalent CAD (per allele OR 1.43, 95% CI 1.07 to 1.91, p = 0.0172); the effect size for the rare rs3798220 variant was similar (dominant OR 1.47, 95% CI 0.81 to 2.67, p = 0.20), but power was limited to demonstrate significance.
|
23735648 |
2013 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our data did not support a relationship between genetic LPA variants (rs6415084 and rs3798220) and subsequent cardiovascular events after PCI in Chinese Han CAD patients.
|
23978127 |
2013 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis.
|
22898070 |
2012 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The LPA I4399M (rs3798220) single nucleotide polymorphism (SNP) is associated with increased plasma levels of Lp(a) and advanced coronary artery disease (CAD).
|
19880117 |
2010 |
|
rs3798220
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found 1 SNP that was associated with severe CAD: LPA I4399M (rs3798220).
|
17569884 |
2007 |
|
rs1801693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We herein genotyped four single nucleotide polymorphisms (SNPs) in lipid metabolism-related genes (rs1132899 and rs5167 in APOC4, rs1801693 and rs7765781 in LPA), aimed to shed light on the influence of these SNPs on individual susceptibility to early-onset CAD.
|
26129832 |
2015 |
|
rs7765781
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We herein genotyped four single nucleotide polymorphisms (SNPs) in lipid metabolism-related genes (rs1132899 and rs5167 in APOC4, rs1801693 and rs7765781 in LPA), aimed to shed light on the influence of these SNPs on individual susceptibility to early-onset CAD.
|
26129832 |
2015 |
|
rs9364559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of haplotype analysis showed that 4 haplotypes which contained rs9364559-G were associated with increased risk of CAD in this population.
|
24790998 |
2014 |
|
rs6415084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants in the rs3798220, rs10455872 and rs6415084 single-nucleotide polymorphisms (SNPs) in the Lp(a) gene (LPA) correlate with elevated Lp(a) levels, but whether these SNPs have prognostic value for CAD patients is unknown.
|
23978127 |
2013 |