|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC.
|
24376578 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In subgroup analysis by ethnicity, the pooled results suggested that the p53 codon 72 Arg/Pro polymorphism was associated with an increased risk of HCC in Asians and Caucasians (for Asians, ORProPro vs. ArgArg + ArgPro=1.17 (95 % CI, 1.02-1.34), P OR=0.025; for Caucasians, ORProPro vs. ArgArg = 1.65 (95 % CI, 1.07-2.56), P OR=0.025; ORProPro vs. ArgArg + ArgPro=1.74 (95 % CI, 1.14-2.66), P OR=0.010).
|
23564481 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC.
|
24376578 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC.
|
24376578 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In subgroup analysis by ethnicity, the pooled results suggested that the p53 codon 72 Arg/Pro polymorphism was associated with an increased risk of HCC in Asians and Caucasians (for Asians, ORProPro vs. ArgArg + ArgPro=1.17 (95 % CI, 1.02-1.34), P OR=0.025; for Caucasians, ORProPro vs. ArgArg = 1.65 (95 % CI, 1.07-2.56), P OR=0.025; ORProPro vs. ArgArg + ArgPro=1.74 (95 % CI, 1.14-2.66), P OR=0.010).
|
23564481 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
rs1064793929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the β-catenin mutation was associ</span>ated with better prognosis in both S100P-positive and -negative HCC</span>s.
|
23785431 |
2013 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, these results support the preferential occurrence of R249S-mutated DNA in HCC developing in the absence of cirrhosis in a context of HBV chronic infection.
|
22675488 |
2012 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These findings suggest that in HCC from The Gambia, complete HBX sequences are often associated with the presence of TP53 R249S mutation.
|
22759751 |
2012 |
|
rs121912656
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Furthermore, p53(G245D) was shown to have a similar pattern of subcellular localization to ZBP-89 in tissues of HCC patients in Hong Kong.
|
22214764 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians.
|
23167333 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians.
|
23167333 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians.
|
23167333 |
2012 |