Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs138213197
rs138213197
HOXB13
0.040 GeneticVariation BEFREE A rare recurrent missense variant in HOXB13 (rs138213197/G84E) was recently reported to be associated with hereditary prostate cancer. 25595936

2015
dbSNP: rs138213197
rs138213197
HOXB13
0.040 GeneticVariation BEFREE A rare but recurrent missense mutation (G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer. 22841674

2014
dbSNP: rs138213197
rs138213197
HOXB13
0.040 GeneticVariation BEFREE Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer. 24722062

2014
dbSNP: rs138213197
rs138213197
HOXB13
0.040 GeneticVariation BEFREE The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. 22236224

2012
dbSNP: rs3803185
rs3803185
ARL11
0.010 GeneticVariation BEFREE This study provides strong confirmation of the important role of ARLTS1 Cys148Arg variant as a contributor in PCa predisposition and a potential marker for aggressive disease outcome. 22028916

2011
dbSNP: rs1114167843
rs1114167843
MSH2
0.010 GeneticVariation BEFREE Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M. 16963262

2006
dbSNP: rs1799977
rs1799977
MLH1
0.010 GeneticVariation BEFREE Carrier frequencies of the I219V mutation were compared between hereditary prostate cancer (HPC) patients, unselected PRCA cases, patients with benign prostate hyperplasia and controls, but no differences between the sample groups were found. 16963262

2006
dbSNP: rs35831931
rs35831931
MLH1
0.010 GeneticVariation BEFREE Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M. 16963262

2006
dbSNP: rs536562413
rs536562413
MSH6 ; FBXO11
0.010 GeneticVariation BEFREE Carrier frequencies of the I219V mutation were compared between hereditary prostate cancer (HPC) patients, unselected PRCA cases, patients with benign prostate hyperplasia and controls, but no differences between the sample groups were found. 16963262

2006
dbSNP: rs63750109
rs63750109
MLH1
0.010 GeneticVariation BEFREE Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M. 16963262

2006
dbSNP: rs486907
rs486907
RNASEL
0.010 GeneticVariation BEFREE Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported. 15534086

2004
dbSNP: rs74315364
rs74315364
RNASEL
0.010 GeneticVariation BEFREE Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported. 15534086

2004
dbSNP: rs627928
rs627928
RNASEL
0.010 GeneticVariation BEFREE To further test for potential associations between genes and increased risk for disease, the three missense polymorphisms (Ile97Leu, Arg462Gln, and Glu541Asp) were genotyped in 438 patients with familial PC and in 510 population-based control subjects. 12022038

2002
dbSNP: rs4792311
rs4792311
ELAC2
0.010 GeneticVariation BEFREE A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population. 11507049

2001
dbSNP: rs5030739
rs5030739
ELAC2
0.010 GeneticVariation BEFREE A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population. 11507049

2001