|
Neoplasm Metastasis
|
0.380 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, high CDH2 expression in TECs was significantly associated with tumor stage, visceral pleural metastasis, and decreased overall survival in patients with ADC but not SCC.
|
30832661 |
2019 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
E-, N-, P-, VE-, Proto-, desmosomal and FAT cadherins have been found to regulate breast cancer in positive as well as negative fashion, whereby both Ecadherin (CDH1) and N-cadherin (CDH2) contribute significantly towards transitioning from epithelial state to mesenchymal state (EMT) and enacting the abnormal cells to invade and metastasize nearby and distant tissues.
|
26825466 |
2016 |
|
Neoplasm Metastasis
|
0.380 |
AlteredExpression
|
phenotype |
BEFREE |
The invasive behavior of TNBC tumor cells surviving short-term chemotherapy treatment in vitro was studied using transwell invasion assays and an experimental metastasis model. mRNA expression levels of neural cadherin (N-cadherin), an adhesion molecule that promotes invasion, was assessed by PCR.
|
27768598 |
2016 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
CDH2 (N-cadherin, a mesenchymal marker of the epithelial-mesenchymal transition) and ADAM9 (a type I transmembrane protein) are related to lung cancer brain metastasis; however, it is unclear how they interact to mediate this metastasis.
|
24705471 |
2014 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
Quantitative reverse transcriptase-polymerase chain reaction revealed down-regulation of critical epithelial-mesenchymal transition genes such as CDH2 and ZEB1 in metastases, suggesting epithelial-mesenchymal transition reversal during metastasis.
|
24012533 |
2014 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R.
|
25096247 |
2014 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
CTD_human |
Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells.
|
23876460 |
2013 |
|
Neoplasm Metastasis
|
0.380 |
AlteredExpression
|
phenotype |
BEFREE |
Major actors of EMT, metalloproteases and components of cellular junctions, were either up-regulated (LOXL2, TWIST, TCF3, MMP2, and MMP1) or down-regulated (KRT19 and CDH2) in SDHB-metastatic tumors compared with nonmetastatic ones.
|
22492777 |
2012 |
|
Neoplasm Metastasis
|
0.380 |
AlteredExpression
|
phenotype |
BEFREE |
These data are further corroborated by a switch in CDH1 and CDH2 expression between metastases from the same patient.
|
20848731 |
2010 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
CTD_human |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
|
27811057 |
2016 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
E-, N-, P-, VE-, Proto-, desmosomal and FAT cadherins have been found to regulate breast cancer in positive as well as negative fashion, whereby both Ecadherin (CDH1) and N-cadherin (CDH2) contribute significantly towards transitioning from epithelial state to mesenchymal state (EMT) and enacting the abnormal cells to invade and metastasize nearby and distant tissues.
|
26825466 |
2016 |
|
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
|
27811057 |
2016 |
|
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
E-, N-, P-, VE-, Proto-, desmosomal and FAT cadherins have been found to regulate breast cancer in positive as well as negative fashion, whereby both Ecadherin (CDH1) and N-cadherin (CDH2) contribute significantly towards transitioning from epithelial state to mesenchymal state (EMT) and enacting the abnormal cells to invade and metastasize nearby and distant tissues.
|
26825466 |
2016 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression.
|
23216791 |
2012 |
|
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression.
|
23216791 |
2012 |
|
Mirror movements disorder
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Here, we report de novo heterozygous pathogenic variants (seven missense, two frameshift) in CDH2 in nine individuals with a syndromic neurodevelopmental disorder characterized by global developmental delay and/or intellectual disability, variable axon pathfinding defects (corpus callosum agenesis or hypoplasia, mirror movements, Duane anomaly), and ocular, cardiac, and genital anomalies.
|
31585109 |
2019 |
|
Intellectual Disability
|
0.310 |
GeneticVariation
|
group |
BEFREE |
Here, we report de novo heterozygous pathogenic variants (seven missense, two frameshift) in CDH2 in nine individuals with a syndromic neurodevelopmental disorder characterized by global developmental delay and/or intellectual disability, variable axon pathfinding defects (corpus callosum agenesis or hypoplasia, mirror movements, Duane anomaly), and ocular, cardiac, and genital anomalies.
|
31585109 |
2019 |
|
Stomach Neoplasms
|
0.310 |
Biomarker
|
group |
LHGDN |
Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression.
|
17512904 |
2007 |
|
Mirror movements disorder
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
N-cadherin mediates cortical organization in the mouse brain.
|
17222817 |
2007 |
|
Intellectual Disability
|
0.310 |
Biomarker
|
group |
GENOMICS_ENGLAND |
N-cadherin mediates cortical organization in the mouse brain.
|
17222817 |
2007 |
|
Stomach Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
|
27811057 |
2016 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
|
27811057 |
2016 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
|
27811057 |
2016 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
|
27811057 |
2016 |