|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Up to 90% of the hamsters injected with Ad12 develop tumors within 3-6 weeks.
|
19429476 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since in the hamster tumor system the loss of Ad12 DNA sequences is still compatible with the oncogenic phenotype, the possibility exists that human tumors, though themselves devoid of viral DNA sequences, could have had cells as precursors which originally carried integrated adenoviral DNA sequences.
|
15177895 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Each Ad12-induced tumor cell carried multiple copies of integrated Ad12 genomes at one chromosomal site which was different for each tumor.
|
14609629 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the concentration of the putative tumour suppressor and co-activator p300 was elevated in cell lines expressing high levels of Ad12-E1A and Ad12-E1B due to an increased half-life.
|
12566694 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings provide the first in vivo evidence that the expression of the Ad12 E1 region gene induces cartinoid tumors associated with the activation of the nuclear oncogenes N-myc and c-jun.
|
7865136 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcriptional down-regulation of the major histocompatibility complex (MHC) class I antigens in adenovirus type 12 (Ad12) transformed cells gives them the potential to escape immunosurveillance and to form tumors.
|
8036004 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Rhim et al. were first to show that superinfection of Ad12-SV40-infected immortalized human epidermal cells with an RNA tumor virus containing a ras oncogene, such as Ki-MSV, or their treatment with chemical carcinogens, leads to the ability of cells to both grow in anchorage-independent fashion and to form tumors in athymic nude mice.
|
8330279 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The Ad12-transformed cells uniformly expressed low levels of class I MHC antigens; these cells produced tumors 200- to 1,000-fold less efficiently in allogeneic adult hamsters than in syngeneic adult hamsters and produced tumors with about the same efficiency in immunoimmature newborns and immunocompetent syngeneic adult hamsters.
|
2839700 |
1988 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, despite the fact that all products required for oncogenic transformation in vitro were derived from the highly oncogenic Ad12, the recombinant virus did not produce tumors in vivo.
|
6328015 |
1984 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inoculation of the Ad5/Ad12 hybrid virus into newborn hamsters did not result in development of tumors.
|
6649414 |
1983 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The levels of expression of the viral genome in the Balb/c tumor and in the retinoblastoma line were determined by in vitro translation of RNA isolated from these cells and selected with appropriate restriction endonuclease fragments of Ad12 DNA.
|
7188349 |
1982 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These observations have led to the suggestion that Ad-12 may also be involved in the induction of human retinoblastoma tumors.
|
7160939 |
1982 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The hamster cell line CLAC1 originated from a tumor induced by injecting human adenovirus type 12 (Ad12) into newborn hamsters.
|
6298706 |
1982 |
|
Retinoblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The levels of expression of the viral genome in the Balb/c tumor and in the retinoblastoma line were determined by in vitro translation of RNA isolated from these cells and selected with appropriate restriction endonuclease fragments of Ad12 DNA.
|
7188349 |
1982 |
|
Retinoblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Analysis of RNA and DNA by blotting with labelled Ad-12 failed to reveal viral sequences in human retinoblastoma.
|
7160939 |
1982 |
|
Lewy Body Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of 114 samples (60 aging controls, 36 Alzheimer's disease, 12 vascular dementia (VaD) and 6 dementia with Lewy bodies (DLB) subjects) were analyzed.
|
31424413 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ad12 E1A inhibits AR-mediated transcription and suppresses PCa cell survival, suggesting that targeting the AR by E1A12 might have therapeutic potential for treating advanced PCa with heightened AR signaling.
|
30009471 |
2018 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ad12 E1A inhibits AR-mediated transcription and suppresses PCa cell survival, suggesting that targeting the AR by E1A12 might have therapeutic potential for treating advanced PCa with heightened AR signaling.
|
30009471 |
2018 |
|
Mild cognitive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Logistic regression models showed that baseline ATOA predicted future clinical diagnoses of MCI and AD 12 years later, while controlling for sociodemographic, genetic, and health variables.
|
29756803 |
2018 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we test the hypothesis that Ad12 E1B 55-kDa oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin.
|
25820823 |
2015 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we test the hypothesis that Ad12 E1B 55-kDa oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin.
|
25820823 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we test the hypothesis that Ad12 E1B 55-kDa oncoprotein promotes p53-mediated apoptotic response of ovarian cancer to cisplatin.
|
25820823 |
2015 |
|
Idiopathic normal pressure hydrocephalus (INPH)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The final clinical diagnoses in a median follow-up of 3.9 years were: 113 iNPH (94 shunt responsive, 16 shunt non-responsive, three not shunted); 36 AD (12 mixed iNPH + AD); 53 others.
|
22955176 |
2012 |
|
Adenovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Increased genetic activity of cellular genes late in adenovirus infection has not been reported previously and demonstrates that Ad12 has a sustained control of host cell gene expression well into the late phase of infection.
|
15681441 |
2005 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
BMK cells transformed by mutant Ad12-E1A (Ad12-E1Am) plus Ad12-E1B via retrovirus-mediated gene transfer showed features comparable to wild-type Ad12-E1A (Ad12-E1Awt) plus Ad12-E1B-transformed cells: they formed foci in soft agar and produced tumours in immunodeficient nude mice, although after a prolonged latency period.
|
12566694 |
2003 |